JAMA Surg:甲状旁腺切除术与原发性甲状旁腺功能亢进症患者高血压症状

2019-10-15 MedSci MedSci原创

甲状旁腺切除术可改善原发性甲状旁腺功能亢进症患者高血压症状

甲状旁腺功能亢进与多种心血管疾病有关,近日研究人员考察了甲状旁腺切除术对原发性甲状旁腺功能亢进症(PHPT)患者高血压的影响。

PHPT伴高血压患者参与研究,比较进行或未进行甲状旁腺切除术患者的平均动脉压(MAP)和抗高血压药物使用情况,分别在术后6个月、1年以及2年进行评估。

2380名患者参与研究,女性占79.0%,501名患者接受甲状旁腺切除术,1879名患者未进行手术,手术患者基线年龄较低(65.3 vs71.9岁),使用的药物种类更少(1.2 vs 1.5)。手术组MAP改善效果优于非手术组:1年,非手术组血压增加0.1mmHg,手术组减少1.2mmHg。非手术组使用抗高血压药物风险增加--6个月药物使用率,15.9 vs 9.8%;1年,18.1 vs 10.8%;2年,17.6 vs 12.2%。多因素分析显示,甲状旁腺切除术与无抗高血压药物使用相关(OR=0.49)。对于基线未接受药物治疗的患者,接受甲状旁腺切除术后服用抗高血压药物的风险降低(10.2% vs 30.4%)。

研究认为,甲状旁腺切除术可改善原发性甲状旁腺功能亢进症患者高血压症状。

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