Int J Cardiol:各种颈动脉超声参数对高和极高心血管风险患者的预后价值

2019-06-18 xing.T 网络

由此可见,在颈动脉粥样硬化标志物中具有高和极高CVR的患者中,仅颈动脉斑块和cTPA对于不良心血管事件的发展具有独立的预测价值。

根据目前的指南颈动脉粥样硬化斑块的可视化是颈动脉超声提供评估心血管风险(CVR)的唯一选择。基于动脉粥样化的量化,致力于开发和实施标志物的方向前景较好。近日,心血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,该研究的目的是评估各种颈动脉超声参数对高CVR和极高CVR患者的预后价值。

该研究纳入了高和极高CVR的患者,所有患者均接受颈动脉超声检查。研究人员评估了颈动脉内膜中层厚度(cIMT)、颈动脉斑块、颈动脉斑块评分(cPS)和颈动脉总斑块面积(cTPA)。联合终点包含心血管死亡、非致命性心肌梗死或不稳定型心绞痛、非致命性卒中和冠状动脉血运重建。

该研究纳入了100名患者,随访期为24.4(14.1-34.3)个月。终点事件发生在34.0%的患者中。cIMT和cPS与心血管事件的风险无显著相关性。在调整可能的混杂因素后,根据Cox回归确定颈动脉斑块的存在与心血管事件的相对风险增加10.5倍相关(95%CI为1.27-86.5; p=0.008)。根据调整分析,CTPA≥69mm2与心血管事件风险增加5.86倍相关(95%CI为2.09-16.4; p=0.001)。

由此可见,在颈动脉粥样硬化标志物中具有高和极高CVR的患者中,仅颈动脉斑块和cTPA对于不良心血管事件的发展具有独立的预测价值。 

原始出处:

Vadim V.Genkel,et al.The prognostic value of various carotid ultrasound parameters in patients at high and very high cardiovascular risk.International Journal of Cardiology.2019.https://doi.org/10.1016/j.ijcard.2019.06.038

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