JAMA:负压创伤疗法不能降低创伤相关骨折术后深度感染风险

2020-02-12 MedSci MedSci原创

研究发现,因严重创伤导致下肢骨折手术患者中,采用切口负压伤口治疗不能减少深度手术部位感染率

手术治疗创伤相关骨折后,患者深度伤口感染率较高。近日研究人员考察了术后负压创伤疗法对感染率的影响。

研究在英国开展,1548名16岁以上,因重大创伤致下肢骨折接受手术患者参与,随机接受负压创伤治疗(通过特殊敷料产生负压,n=785)或标准伤口敷料(n=763)。研究的主要终点为30天深度伤口感染率,次要终点包括90天深度伤口感染率、患者报告的残疾、生活质量、手术疤痕、慢性疼痛以及伤口愈合并发症。

患者平均年龄49.8岁,其中40岁以下患者占36%,女占38%,57%的患者存在多处损伤。30天,负压组深度伤口感染率为5.84%(45/770),标准治疗组为6.68%(50/749,OR=0.87,绝对风险差异为-0.77%)。组间90天深度伤口感染率无显著差异(11.4% vs 13.2%,OR=0.84),其他次要终点也无显著差异。

研究发现,因严重创伤导致下肢骨折手术患者中,采用切口负压伤口治疗不能减少深度手术部位感染率。

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