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Biomed Mater：3D打印凝胶可有效恢复骨缺损

2019-10-13 不详 网络

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三维（3D）打印技术为定制外部形状以及骨骼支架的内部结构开辟了新的视角。在这项研究中，将源自骨形态发生蛋白2的寡肽（SSVPT，Ser-Ser-Val-Pro-Thr）与3D打印的聚乳酸（PLA）支架的多巴胺涂层偶联，以增强成骨作用。体外细胞实验表明，该支架对大鼠骨髓间充质干细胞（MSCs）的粘附和增殖具有高度的骨传导性。此外，RT-PCR分析显示该支架可以促进成骨相关基因的表达，例如碱性磷酸酶（

三维（3D）打印技术为定制外部形状以及骨骼支架的内部结构开辟了新的视角。在这项研究中，将源自骨形态发生蛋白2的寡肽（SSVPT，Ser-Ser-Val-Pro-Thr）与3D打印的聚乳酸（PLA）支架的多巴胺涂层偶联，以增强成骨作用。

体外细胞实验表明，该支架对大鼠骨髓间充质干细胞（MSCs）的粘附和增殖具有高度的骨传导性。此外，RT-PCR分析显示该支架可以促进成骨相关基因的表达，例如碱性磷酸酶（ALP），矮子相关转录因子2（RUNX2），骨钙蛋白（OCN）和骨桥蛋白（OPN）。大鼠颅骨缺损模型micro-CT 3D重建图像显示，骨组织从仿生肽水凝胶的一侧边缘向中心区域生长，表明骨再生明显加速。

总之，这项工作将为进一步探索这种生物活性支架的应用潜力提供基础。

原始出处：

Zhang X, Lou Q, et al., Immobilization of BMP-2-derived peptides on 3D-printed porous scaffolds for enhanced osteogenesis. Biomed Mater. 2019 Oct 9. doi: 10.1088/1748-605X/ab4c78.

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    2020-06-13 sunylz

    #Bio#

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    2019-10-15 ms9833124466084992

    #3D#

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    2019-10-15 lfcmxl

    #骨缺损#

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    2019-10-15 智慧医人

    #凝胶#

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    2019-10-15 ms3994565386320060

    #Med#

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