Science:新发现生长因子PIGF-2可加速伤口愈合再生

2014-02-26 中国科技网 中国科技网

杀死比尔剧照 新华社日内瓦2月24日电 瑞士洛桑联邦工学院的科研人员日前发表研究公报称,一种名为“PIGF-2”的生长因子可以大大促进机体组织的生长,加速伤口愈合。这一发现将有助于再生药物研究。人体受伤后通常会自我修复受损组织,这一过程是由一种被称为生长因子的蛋白质所控制的。细胞内的生长因子可以加速伤口愈合,避免失血过多及并发症,对胚胎发育也很重要。   生长因子则是通过聚合一


杀死比尔剧照

瑞士洛桑联邦工学院的科研人员日前发表研究公报称,一种名为“PIGF-2”的生长因子可以大大促进机体组织的生长,加速伤口愈合。这一发现将有助于再生药物研究。

人体受伤后通常会自我修复受损组织,这一过程是由一种被称为生长因子的蛋白质所控制的。细胞内的生长因子可以加速伤口愈合,避免失血过多及并发症,对胚胎发育也很重要。   生长因子则是通过聚合一种名为“细胞外基质”的蛋白质来促进机体组织细胞的生长。细胞外基质好比机体组织的“框架”,通常情况下,生长因子聚合细胞外基质的能力越强,伤口愈合得越快。但目前含有生长因子成分的药物却往往效果不佳,无法到达天然生长因子在人体内的修复效果。   洛桑联邦工学院教授杰弗里·哈贝尔领导的研究小组对25种生长因子进行了动物实验,结果发现,“PIGF-2”生长因子对细胞外基质的聚合能力最强,促进组织器官修复的效率最高。   研究人员将一部分“PIGF-2”生长因子与其他三种修复效率较低的生长因子相融合,结果发现,它们对细胞外基质的聚合能力增加了近100倍,从而在未来或可大大减少生长因子药物的使用剂量。此外,经过生物工程技术处理而相互融合的生长因子,能加快血液凝块结痂,进一步提高伤口愈合效果。   目前研究人员仅对实验鼠进行了动物研究,他们还将展开更多的动物实验,并最终用于人体。这一研究成果已发表在新一期的美国《科学》杂志上。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=12349, encodeId=c5341234960, content=当人体受伤时体内的组织生长因子水平,是否很高。伤后一周内不需要补充。这个观点对吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba0a1604518, createdName=wbz951729, createdTime=Tue Oct 28 09:42:00 CST 2014, time=2014-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=12348, encodeId=d6e21234886, content=本刊发表的论文,均是现代医学学术前沿,很新颖。我深感兴趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba0a1604518, createdName=wbz951729, createdTime=Tue Oct 28 09:39:00 CST 2014, time=2014-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921095, encodeId=8d86192109511, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Sat Jan 31 05:04:00 CST 2015, time=2015-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039521, encodeId=645a2039521c1, content=<a href='/topic/show?id=ca1294914d' target=_blank style='color:#2F92EE;'>#IGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9491, encryptionId=ca1294914d, topicName=IGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9dd613, createdName=xxxx1049, createdTime=Tue Mar 25 21:04:00 CST 2014, time=2014-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309844, encodeId=cc8a1309844ea, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Fri Feb 28 02:04:00 CST 2014, time=2014-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374837, encodeId=4b5413e483715, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Fri Feb 28 02:04:00 CST 2014, time=2014-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517940, encodeId=561c151e94055, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Fri Feb 28 02:04:00 CST 2014, time=2014-02-28, status=1, ipAttribution=)]
    2014-10-28 wbz951729

    当人体受伤时体内的组织生长因子水平,是否很高。伤后一周内不需要补充。这个观点对吗?

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=12349, encodeId=c5341234960, content=当人体受伤时体内的组织生长因子水平,是否很高。伤后一周内不需要补充。这个观点对吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba0a1604518, createdName=wbz951729, createdTime=Tue Oct 28 09:42:00 CST 2014, time=2014-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=12348, encodeId=d6e21234886, content=本刊发表的论文,均是现代医学学术前沿,很新颖。我深感兴趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba0a1604518, createdName=wbz951729, createdTime=Tue Oct 28 09:39:00 CST 2014, time=2014-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921095, encodeId=8d86192109511, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Sat Jan 31 05:04:00 CST 2015, time=2015-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039521, encodeId=645a2039521c1, content=<a href='/topic/show?id=ca1294914d' target=_blank style='color:#2F92EE;'>#IGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9491, encryptionId=ca1294914d, topicName=IGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9dd613, createdName=xxxx1049, createdTime=Tue Mar 25 21:04:00 CST 2014, time=2014-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309844, encodeId=cc8a1309844ea, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Fri Feb 28 02:04:00 CST 2014, time=2014-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374837, encodeId=4b5413e483715, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Fri Feb 28 02:04:00 CST 2014, time=2014-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517940, encodeId=561c151e94055, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Fri Feb 28 02:04:00 CST 2014, time=2014-02-28, status=1, ipAttribution=)]
    2014-10-28 wbz951729

    本刊发表的论文,均是现代医学学术前沿,很新颖。我深感兴趣

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=12349, encodeId=c5341234960, content=当人体受伤时体内的组织生长因子水平,是否很高。伤后一周内不需要补充。这个观点对吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba0a1604518, createdName=wbz951729, createdTime=Tue Oct 28 09:42:00 CST 2014, time=2014-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=12348, encodeId=d6e21234886, content=本刊发表的论文,均是现代医学学术前沿,很新颖。我深感兴趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba0a1604518, createdName=wbz951729, createdTime=Tue Oct 28 09:39:00 CST 2014, time=2014-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921095, encodeId=8d86192109511, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Sat Jan 31 05:04:00 CST 2015, time=2015-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039521, encodeId=645a2039521c1, content=<a href='/topic/show?id=ca1294914d' target=_blank style='color:#2F92EE;'>#IGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9491, encryptionId=ca1294914d, topicName=IGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9dd613, createdName=xxxx1049, createdTime=Tue Mar 25 21:04:00 CST 2014, time=2014-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309844, encodeId=cc8a1309844ea, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Fri Feb 28 02:04:00 CST 2014, time=2014-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374837, encodeId=4b5413e483715, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Fri Feb 28 02:04:00 CST 2014, time=2014-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517940, encodeId=561c151e94055, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Fri Feb 28 02:04:00 CST 2014, time=2014-02-28, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=12349, encodeId=c5341234960, content=当人体受伤时体内的组织生长因子水平,是否很高。伤后一周内不需要补充。这个观点对吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba0a1604518, createdName=wbz951729, createdTime=Tue Oct 28 09:42:00 CST 2014, time=2014-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=12348, encodeId=d6e21234886, content=本刊发表的论文,均是现代医学学术前沿,很新颖。我深感兴趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba0a1604518, createdName=wbz951729, createdTime=Tue Oct 28 09:39:00 CST 2014, time=2014-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921095, encodeId=8d86192109511, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Sat Jan 31 05:04:00 CST 2015, time=2015-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039521, encodeId=645a2039521c1, content=<a href='/topic/show?id=ca1294914d' target=_blank style='color:#2F92EE;'>#IGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9491, encryptionId=ca1294914d, topicName=IGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9dd613, createdName=xxxx1049, createdTime=Tue Mar 25 21:04:00 CST 2014, time=2014-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309844, encodeId=cc8a1309844ea, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Fri Feb 28 02:04:00 CST 2014, time=2014-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374837, encodeId=4b5413e483715, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Fri Feb 28 02:04:00 CST 2014, time=2014-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517940, encodeId=561c151e94055, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Fri Feb 28 02:04:00 CST 2014, time=2014-02-28, status=1, ipAttribution=)]
    2014-03-25 xxxx1049
  5. [GetPortalCommentsPageByObjectIdResponse(id=12349, encodeId=c5341234960, content=当人体受伤时体内的组织生长因子水平,是否很高。伤后一周内不需要补充。这个观点对吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba0a1604518, createdName=wbz951729, createdTime=Tue Oct 28 09:42:00 CST 2014, time=2014-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=12348, encodeId=d6e21234886, content=本刊发表的论文,均是现代医学学术前沿,很新颖。我深感兴趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba0a1604518, createdName=wbz951729, createdTime=Tue Oct 28 09:39:00 CST 2014, time=2014-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921095, encodeId=8d86192109511, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Sat Jan 31 05:04:00 CST 2015, time=2015-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039521, encodeId=645a2039521c1, content=<a href='/topic/show?id=ca1294914d' target=_blank style='color:#2F92EE;'>#IGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9491, encryptionId=ca1294914d, topicName=IGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9dd613, createdName=xxxx1049, createdTime=Tue Mar 25 21:04:00 CST 2014, time=2014-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309844, encodeId=cc8a1309844ea, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Fri Feb 28 02:04:00 CST 2014, time=2014-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374837, encodeId=4b5413e483715, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Fri Feb 28 02:04:00 CST 2014, time=2014-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517940, encodeId=561c151e94055, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Fri Feb 28 02:04:00 CST 2014, time=2014-02-28, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=12349, encodeId=c5341234960, content=当人体受伤时体内的组织生长因子水平,是否很高。伤后一周内不需要补充。这个观点对吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba0a1604518, createdName=wbz951729, createdTime=Tue Oct 28 09:42:00 CST 2014, time=2014-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=12348, encodeId=d6e21234886, content=本刊发表的论文,均是现代医学学术前沿,很新颖。我深感兴趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba0a1604518, createdName=wbz951729, createdTime=Tue Oct 28 09:39:00 CST 2014, time=2014-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921095, encodeId=8d86192109511, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Sat Jan 31 05:04:00 CST 2015, time=2015-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039521, encodeId=645a2039521c1, content=<a href='/topic/show?id=ca1294914d' target=_blank style='color:#2F92EE;'>#IGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9491, encryptionId=ca1294914d, topicName=IGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9dd613, createdName=xxxx1049, createdTime=Tue Mar 25 21:04:00 CST 2014, time=2014-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309844, encodeId=cc8a1309844ea, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Fri Feb 28 02:04:00 CST 2014, time=2014-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374837, encodeId=4b5413e483715, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Fri Feb 28 02:04:00 CST 2014, time=2014-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517940, encodeId=561c151e94055, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Fri Feb 28 02:04:00 CST 2014, time=2014-02-28, status=1, ipAttribution=)]
    2014-02-28 jichang
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