J Clin Oncol:派姆单抗治疗难治性转移去势抵抗性前列腺癌研究

2019-12-05 AlexYang MedSci原创

之前的研究报道了派姆单抗对程序性死亡配体1(PD-L1)阳性转移去势抵抗性前列腺癌(mCRPC)具有抗肿瘤活性。最近,有研究人员评估了派姆单抗在一个更大的mCRPC群体中的3个平行群体中的抗肿瘤活性和安全性情况。研究共包括了258名患者:群体1中包含133名,群体2中包含66名,群体3中包含59名。群体1中客观反映率为5%(95% CI, 2%到11%),群体2中客观反映率为3%(95% CI,

之前的研究报道了派姆单抗对程序性死亡配体1(PD-L1)阳性转移去势抵抗性前列腺癌(mCRPC)具有抗肿瘤活性。最近,有研究人员评估了派姆单抗在一个更大的mCRPC群体中的3个平行群体中的抗肿瘤活性和安全性情况。

研究共包括了258名患者:群体1中包含133名,群体2中包含66名,群体3中包含59名。群体1中客观反映率为5%(95% CI, 2%到11%),群体2中客观反映率为3%(95% CI, < 1%到11%)。在群体1中和群体2中响应持续的时间分别为没有达到(范围,1.9到≥21.8个月)和10.6个月(范围4.4到16.8个月)。疾病控制率在群体1、2和3中分别为10%、9%和22%。群体1、2和3中OS均值分别为9.5个月、7.9个月和14.1个月。治疗相关的副作用事件在60%的患者中发生,并且15%的等级严重度为3到5,且导致治疗中断比例为5%。

最后,研究人员指出,派姆单抗治疗在多烯紫杉醇和靶向内分泌治疗的RESIST可测量和骨优势mCRPC患者中表现出了抗肿瘤活性,且安全性可以接受。另外,观察的响应应该是持久的,并且OS也让人满意。

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    2020-06-18 yige2012
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    2020-01-10 minlingfeng
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    2019-12-06 健康达人

    肿瘤免疫是大家关心的话题,K药与其它药对比,值得关注!

    0

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    2019-12-06 anti-cancer

    谢谢梅斯分享这么多精彩信息

    0

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    2019-12-06 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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