Mater Sci Eng C Mater Biol Appl:新的方法成功设计三维支架可用于组织工程

2019-01-11 MedSci MedSci原创

本文提出了一种有效的组织工程三维(3D)分层多孔支架设计方法。为了实现具有精确控制的内部孔结构的这种分层多孔结构,提出了递归交叉布尔运算(RIBO)以满足多孔支架的计算效率和生物功能要求。 结果显示,在为给定的解剖模型和所需的孔结构生成距离场(DF)之后,递归DF修改后能够设计具有孔形态的复杂组合的分层多孔支架。 各种实验结果表明,所提出的分层多孔支架设计方法具有精确控制孔隙度和孔隙结构梯度的潜在

本文提出了一种有效的组织工程三维(3D)分层多孔支架设计方法。为了实现具有精确控制的内部孔结构的这种分层多孔结构,提出了递归交叉布尔运算(RIBO)以满足多孔支架的计算效率和生物功能要求。

结果显示,在为给定的解剖模型和所需的孔结构生成距离场(DF)之后,递归DF修改后能够设计具有孔形态的复杂组合的分层多孔支架。

各种实验结果表明,所提出的分层多孔支架设计方法具有精确控制孔隙度和孔隙结构梯度的潜在优势,同时保留了三重周期性最小表面孔隙几何形状的优点。

原始出处:

Yoo D. New paradigms in hierarchical porous scaffold design for tissue engineering. Mater Sci Eng C Mater Biol Appl. 2013 Apr 1;33(3):1759-72. doi: 10.1016/j.msec.2012.12.092.

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    2019-05-29 sunylz
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    2019-06-07 spoonycyy
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