Crit Care:重症监护病房烧伤患者的急性肾损伤

2020-01-03 xing.T MedSci原创

由此可见,38%入住ICU的烧伤患者发生AKI,所有患者中有12%接受了RRT。AKI的发生与LOS和死亡率增加相关。

急性肾脏损伤(AKI)是入住重症监护病房(ICU)烧伤患者常见的并发症,并与发病率和死亡率增加有关。近日,危重病医学领域权威杂志Critical Care上发表了一篇研究文章,研究人员旨在评估入住ICU的烧伤患者AKI发生率、危险因素和结局。次要目的是评估肾脏替代疗法(RRT)及其对医疗保健费用的影响。

截止到2018年12月3日,研究人员对PubMed、UpToDate和NICE进行了系统的检索。除协议外,所有Cochrane系统评价数据库中的评价均添加到PubMed检索中。研究人员根据风险、损伤、衰竭、肾功能丧失和晚期肾病(RIFLE)检索了有关AKI的研究;急性肾脏损伤网络(AKIN);和/或肾脏疾病:改善了入住ICU的烧伤患者的总体预后(KDIGO)标准。研究人员收集了有关AKI发生率、危险因素、RRT的使用情况、肾脏恢复、住院时间(LOS)、死亡率和医疗保健费用等数据。

研究人员纳入了33项观察性研究,涉及8200例患者。根据纽卡斯尔-渥太华量表评分的总体研究质量中等。随机效应模型荟萃分析显示,入住ICU的烧伤患者中AKI的发生率为38(30-46)%。AKI患者在轻度、中度和重度AKI亚组中几乎均匀分布。在所有患者中,有12(8-16)%患者使用了RRT。 AKI的危险因素包括高龄、慢性高血压糖尿病、烧伤总表面积较大、高烧伤严重度指数评分、吸入性损伤、横纹肌溶解、手术、高急性生理和慢性健康评估II评分、高顺序器官衰竭高评估评分、败血症和机械通​气。与非AKI患者相比,AKI患者的ICU LOS时间要长8.6(4.0-13.2)天,死亡率更高,OR为11.3(7.3-17.4)。很少有研究报告有肾脏恢复,没有研究报告了医疗费用。

由此可见,38%入住ICU的烧伤患者发生AKI,所有患者中有12%接受了RRT。AKI的发生与LOS和死亡率增加相关。

原始出处:

Torgeir Folkestad.et al.Acute kidney injury in burn patients admitted to the intensive care unit: a systematic review and meta-analysis.Critical Care.2019.https://ccforum.biomedcentral.com/articles/10.1186/s13054-019-2710-4

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    2020-12-25 taken110

    感谢分享!

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    2020-01-05 bioon6
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    2020-01-04 1ddf0692m34(暂无匿称)

    学习了,谢谢分享

    0

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