JAHA:中度主动脉狭窄患者的远期预后研究

2019-03-08 不详 MedSci原创

中度主动脉狭窄(MAS)尚未被研究的十分清楚。本研究的目的旨在评估MAS患者的临床特征和远期预后。本研究纳入了508例MAS伴保留型左室射血分数的患者(平均年龄 75±11岁)。大多数患者(86.4%)无临床症状或很轻,78.3%的患者有高血压,36.2%的患者有糖尿病,48.3%的患者有血脂异常。经过平均47个月时间的随访,113名(22.2%)患者因严重AS接受了主动脉瓣置换术,入组到手术的平

中度主动脉狭窄(MAS)尚未被研究的十分清楚。本研究的目的旨在评估MAS患者的临床特征和远期预后。

本研究纳入了508例MAS伴保留型左室射血分数的患者(平均年龄 75±11岁)。大多数患者(86.4%)无临床症状或很轻,78.3%的患者有高血压,36.2%的患者有糖尿病,48.3%的患者有血脂异常。经过平均47个月时间的随访,113名(22.2%)患者因严重AS接受了主动脉瓣置换术,入组到手术的平均时间为37±22个月,随访期间,255名患者死亡。MAS患者的6年生存率低于预期(53±2% vs 65%)。多元回归分析后发现,年龄(HR:1.04 [95% CI, 1.02–1.05]; P<0.001)、房颤病史(HR:1.35 [95% CI, 1.05–1.73]; P=0.019)和查尔森共病指数(HR:1.11 [95% CI, 1.05–1.18]; P=0.002)与死亡率的增高相关。另外,主动脉瓣的置换与更高的生存率相关(HR:0.38 [95% CI, 0.27–0.54]; P<0.001)。

研究结果显示,中度主动脉瓣狭窄患者的血管危险因素较多,手术率较高,远期生存率低于预期。

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    2019-03-10 zhaohui6731
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