EAU18∣仁济之声,分享肾癌及尿路上皮癌两项研究成果

2018-03-24 佚名 肿瘤瞭望

肾癌及尿路上皮癌两项研究成果

RCC合并癌栓的新辅助治疗需谨慎

肾细胞癌是肾肿瘤最常见的类型,在所有肿瘤中达到了2-3%,其发生率在世界范围内逐年上升。癌栓是肿瘤常见的并发症之一,是指癌细胞在生长、繁殖、转移过程中,侵袭或堆集血管和淋巴系统。新辅助治疗在合并癌栓的肾细胞癌患者中的作用目前仍有争议。

当地时间3月16日上午的转移性肾癌专题报告中,仁济医院黄吉炜医生做题为“Sunitimib or sorafenib as neoadjuvant therapy may not improve the survival outcomes of renal cell carcinoma with tumor thrombus”的报告(poster NO.10)。该研究表明,对于合并癌栓的肾细胞癌患者,新辅助治疗仅能使一部分患者达到降期,且新辅助治疗后行手术相较于直接手术,并没有显着延长患者的无复发生存期和总生存期。因此,对于合并癌栓的肾细胞癌患者是否行新辅助治疗需要谨慎考虑。



UTUC患者切缘状态和预后相关

上尿路尿路上皮肿瘤(Upper Tract Urothelial Carcinoma, UTUC)是一种较为少见但恶性程度较高的泌尿系统肿瘤。很多病理因素与其预后有关,如肿瘤分期分级,肿瘤大小,淋巴结转移等。而切缘状态与UTUC预后的关系目前国内外鲜有报道。

当地时间3月19日下午,仁济医院袁易初博士在“Poster session-Urothelial carcinoma of the upper tract: New options, new strategies and personalised management”环节中做了“切缘不典型增生对行根治手术的上尿路尿路上皮癌预后的影响”的报告(poster NO.1203)。

该团队通过大样本量的研究表明,切缘不典型增生的患者伴随更高的肿瘤分期及淋巴血管侵犯等特征,且对行根治手术的UTUC患者在膀胱内复发有显着影响,而对于总生存期及肿瘤特异性生存期则无明显影响。因此,加强对切缘不典型增生的上尿路尿路上皮癌患者的随访或可使其获益。



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    2019-02-06 839640778
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    2018-03-24 changjiu

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