Arthritis Rheumatol:哮喘、过敏性疾病、被动吸烟与类风湿性关节炎的风险

2019-02-20 xiangting MedSci原创

哮喘和过敏可能与患RA的风险升高相关。被动吸烟和开始吸烟年龄较小似乎并不会影响RA风险。

类风湿性关节炎(RA)被假定起源于粘膜表面,尤其是气道粘膜。为了调查这一假设,这项研究确定了RA与哮喘、被动吸烟和开始吸烟年龄之间的关联。

这项病例对照研究在一个单中心生物库人群中确定了1,023例RA患者(175例偶发性),使用自我报告与两个诊断代码结合基于规则的算法。在生物库问卷上自我报告暴露情况。调整了潜在混杂因素后,使用Logistic回归模型计算暴露与RA的关联。

在调整过敏、城市环境和被动吸烟暴露后,整个队列中哮喘与RA相关(OR 1.28,95%CI 1.04-1.58),但在偶发性队列中不相关(OR 1.17,95%CI 0.66-2.06)。整个队列(OR 1.30,95%CI 1.12-1.51)和偶发性队列(OR 1.61,95%CI 1.11-2.33)中过敏性疾病病史均与RA相关,尤其是食物过敏(分别为OR 1.38,95%CI 1.08-1.75,和OR 1.83,95%CI 0.97-3.45)。家庭或工作场所的被动吸烟与RA无关。最后,整个队列(OR 1.03,95%CI 1.00-1.06)或偶发性队列(OR 1.00,95%CI 0.92-1.08)中,开始吸烟的年龄与发生RA的几率增加无关。

哮喘和过敏可能与患RA的风险升高相关。被动吸烟和开始吸烟年龄较小似乎并不会影响RA风险。

原始出处:

Vanessa L Kronzer. Investigating asthma, allergic disease, passive smoke exposure, and risk of rheumatoid arthritis. Arthritis Rheumatol. 12 February 2019.

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    2019-02-22 lmm397
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    2019-02-22 zhaojie88
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