Circ J:HCV抗病毒治疗减少了心力衰竭等心血管事件的发生

2018-03-07 MedSci MedSci原创

抗病毒治疗CHC,有助于减少住院患者发生心力衰竭、血管事件和心血管死亡事件的发生

研究背景:虽然,HCV是心脏疾病的危险因素,然而,抗病毒治疗是否会减少心里衰竭,目前仍然未知。

研究方法:在这个以住院患者为基础的队列研究中,研究采用来自台湾国家健康保险研究数据库的数据来评估干扰素治疗对慢性丙型肝炎患者心血管事件的影响。评估的临床结果包括:心力衰竭住院、急性心肌梗死、缺血性休克、动脉疾病、全因死亡和心血管死亡。

研究结果:在83,229例慢性丙型肝炎感染患者中,研究比较了16284例患者(接受以干扰素为基础治疗)在倾向评分匹配后未接受治疗的患者。相比未接受以干扰素为基础治疗的患者,接受以干扰素为基础治疗的患者,因心衰而住院的可能性较小(发病率:0.9 vs. 1.5 事件/10(3)人年;风险比(HR)0.58;95%置信区间(CI):0.42-0.79;P=0.001).。与未接受治疗的患者相比,治疗组患者发生复合血管事件 (发病率:3.7 vs. 5.0事件/ 10(3)人年;P<0.001)、全因死亡(发病率:5.6 vs. 17.2事件/ 10(3)人年;P<0.001)和心血管死亡(发病率: 0.2和0.6事件/ 10(3)人年;P = 0.001)的风险显著降低。

研究结论:抗病毒治疗CHC,有助于减少住院患者发生心力衰竭、血管事件和心血管死亡事件的发生。

原始出处

Lin MS, Chung CM, Chang ML, et al. The Unraveled Link between Antiviral Therapy and Heart Failure Hospitalization in Chronic Hepatitis C Virus Infection- A Nationwide Cohort Study. Circ J, 2018, Mar 2. doi: 10.1253/circj.CJ-17-1118.

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    2018-03-09 ymljack
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    2018-03-09 yahu
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    2018-03-08 changjiu

    学习一下谢谢

    0

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    2018-03-07 紫迎馨

    感谢分享

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