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Sci Rep:抗IL-6洗脱免疫调节生物材料延长皮肤同种异体移植物存活

2019-05-19 不详 网络

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治疗烧伤的主要目标是早期闭合伤口。皮肤同种异体移植物的使用是治疗严重烧伤患者的救生策略，但是最终排斥限制了其潜在功效和效用。IL-6是一种主要的多效细胞因子，它与先天性和适应性免疫反应密切相关。在这里，我们设计了抗IL-6受体洗脱明胶甲基丙烯酰（GelMA）生物材料（GelMA /抗IL-6），将其植入伤口床和皮肤同种异体移植物之间的界面。结果显示，可见光交联的GelMA /抗IL-6免疫调节生物

治疗烧伤的主要目标是早期闭合伤口。皮肤同种异体移植物的使用是治疗严重烧伤患者的救生策略，但是最终排斥限制了其潜在功效和效用。IL-6是一种主要的多效细胞因子，它与先天性和适应性免疫反应密切相关。在这里，我们设计了抗IL-6受体洗脱明胶甲基丙烯酰（GelMA）生物材料（GelMA /抗IL-6），将其植入伤口床和皮肤同种异体移植物之间的界面。

结果显示，可见光交联的GelMA /抗IL-6免疫调节生物材料（IMB）具有稳定的抗IL-6的动力学释放曲线。此外，在GelMA水凝胶中掺入抗IL-6对水凝胶的机械性能没有影响。使用高度严格的皮肤移植模型，GelMA /抗IL-6 IMB几乎使皮肤同种异体移植物的存活率翻倍。在延长皮肤同种异体移植物存活中，使用GelMA /抗IL-6 IMB远远优于全身性抗IL-6受体治疗。与未处理的对照组相比，来自GelMA /抗IL-6 IMB组的皮肤含有明显更少的同种异体反应性T细胞和巨噬细胞。有趣的是，植入GelMA /抗IL-6 IMB的小鼠的引流淋巴结（DLN）的环境环境也相当不那么促炎。与GelMA组相比，GelMA /抗IL-6 IMB组的DLN中CD4 +IFNγ+细胞的百分比低得多。

总之，这些结果突出了局部免疫传递在延长皮肤同种异体移植物存活中的重要性及其在治疗严重烧伤患者中的潜在用途。

原始出处：

Uehara M, Li X1, Sheikhi A, et al., Anti-IL-6 eluting immunomodulatory biomaterials prolong skin allograft survival. Sci Rep. 2019 Apr 25;9(1):6535. doi: 10.1038/s41598-019-42349-w.

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    2020-01-23 12498768m22(暂无昵称)

    #同种异体#

    0

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    2019-10-18 xuyong535

    #植物#

    0

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14:06:34 CST 2019, time=2019-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366445, encodeId=4caa366445db, content=学习到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/05/19/1bcf1f4b388b5896583c0ccff1d4827e.jpg, createdBy=429b2531770, createdName=Zpril, createdTime=Sun May 19 14:00:01 CST 2019, time=2019-05-19, status=1, ipAttribution=)]
    2020-04-01 1249857fm32暂无昵称

    #生物材#

    0

  4. 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14:06:34 CST 2019, time=2019-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366445, encodeId=4caa366445db, content=学习到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/05/19/1bcf1f4b388b5896583c0ccff1d4827e.jpg, createdBy=429b2531770, createdName=Zpril, createdTime=Sun May 19 14:00:01 CST 2019, time=2019-05-19, status=1, ipAttribution=)]
    2019-05-21 龙胆草

    学习谢谢分享

    0

  5. 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14:06:34 CST 2019, time=2019-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366445, encodeId=4caa366445db, content=学习到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/05/19/1bcf1f4b388b5896583c0ccff1d4827e.jpg, createdBy=429b2531770, createdName=Zpril, createdTime=Sun May 19 14:00:01 CST 2019, time=2019-05-19, status=1, ipAttribution=)]
    2019-05-20 kzlchina

    #IL-6#

    0

  6. 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14:06:34 CST 2019, time=2019-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366445, encodeId=4caa366445db, content=学习到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/05/19/1bcf1f4b388b5896583c0ccff1d4827e.jpg, createdBy=429b2531770, createdName=Zpril, createdTime=Sun May 19 14:00:01 CST 2019, time=2019-05-19, status=1, ipAttribution=)]
    2019-05-20 dongjia2013

    #生物材料#

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=1620733, encodeId=d8aa1620e3351, content=<a href='/topic/show?id=c0c9e520310' target=_blank style='color:#2F92EE;'>#移植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75203, encryptionId=c0c9e520310, topicName=移植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=153620156575, createdName=10518100zz, createdTime=Mon May 20 17:10:00 CST 2019, time=2019-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366446, encodeId=5d46366446e5, content=真的很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/05/19/1bcf1f4b388b5896583c0ccff1d4827e.jpg, createdBy=429b2531770, createdName=Zpril, createdTime=Sun May 19 14:06:34 CST 2019, time=2019-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366445, encodeId=4caa366445db, content=学习到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/05/19/1bcf1f4b388b5896583c0ccff1d4827e.jpg, createdBy=429b2531770, createdName=Zpril, createdTime=Sun May 19 14:00:01 CST 2019, time=2019-05-19, status=1, ipAttribution=)]
    2019-05-20 jianjun71

    #异体移植#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1687986, encodeId=b3a8168e98637, content=<a href='/topic/show?id=b3e73898423' target=_blank style='color:#2F92EE;'>#同种异体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38984, encryptionId=b3e73898423, topicName=同种异体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23b928427427, createdName=12498768m22(暂无昵称), createdTime=Thu Jan 23 18:10:00 CST 2020, time=2020-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745316, encodeId=ac2a1e45316e7, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue May 21 07:59:43 CST 2019, time=2019-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273782, encodeId=c35212e378290, content=<a href='/topic/show?id=fae896e7ea' target=_blank style='color:#2F92EE;'>#IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Mon May 20 17:10:00 CST 2019, time=2019-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503001, encodeId=bd6f150300192, content=<a href='/topic/show?id=129069358ec' target=_blank style='color:#2F92EE;'>#生物材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69358, encryptionId=129069358ec, topicName=生物材料)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89399597484, createdName=dongjia2013, createdTime=Mon May 20 17:10:00 CST 2019, time=2019-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551648, encodeId=5a2c1551648f0, content=<a href='/topic/show?id=e68d49e39c2' target=_blank style='color:#2F92EE;'>#异体移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49739, encryptionId=e68d49e39c2, topicName=异体移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bf7414204531, createdName=jianjun71, createdTime=Mon May 20 17:10:00 CST 2019, time=2019-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620733, encodeId=d8aa1620e3351, content=<a href='/topic/show?id=c0c9e520310' target=_blank style='color:#2F92EE;'>#移植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75203, encryptionId=c0c9e520310, topicName=移植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=153620156575, createdName=10518100zz, createdTime=Mon May 20 17:10:00 CST 2019, time=2019-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366446, encodeId=5d46366446e5, content=真的很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/05/19/1bcf1f4b388b5896583c0ccff1d4827e.jpg, createdBy=429b2531770, createdName=Zpril, createdTime=Sun May 19 14:06:34 CST 2019, time=2019-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366445, encodeId=4caa366445db, content=学习到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/05/19/1bcf1f4b388b5896583c0ccff1d4827e.jpg, createdBy=429b2531770, createdName=Zpril, createdTime=Sun May 19 14:00:01 CST 2019, time=2019-05-19, status=1, ipAttribution=)]
    2019-05-20 10518100zz

    #移植物#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1687986, encodeId=b3a8168e98637, content=<a href='/topic/show?id=b3e73898423' target=_blank style='color:#2F92EE;'>#同种异体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38984, encryptionId=b3e73898423, topicName=同种异体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23b928427427, createdName=12498768m22(暂无昵称), createdTime=Thu Jan 23 18:10:00 CST 2020, time=2020-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745316, encodeId=ac2a1e45316e7, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69358, encryptionId=129069358ec, topicName=生物材料)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89399597484, createdName=dongjia2013, createdTime=Mon May 20 17:10:00 CST 2019, time=2019-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551648, encodeId=5a2c1551648f0, content=<a href='/topic/show?id=e68d49e39c2' target=_blank style='color:#2F92EE;'>#异体移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49739, encryptionId=e68d49e39c2, topicName=异体移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bf7414204531, createdName=jianjun71, createdTime=Mon May 20 17:10:00 CST 2019, time=2019-05-20, status=1, ipAttribution=), 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14:06:34 CST 2019, time=2019-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366445, encodeId=4caa366445db, content=学习到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/05/19/1bcf1f4b388b5896583c0ccff1d4827e.jpg, createdBy=429b2531770, createdName=Zpril, createdTime=Sun May 19 14:00:01 CST 2019, time=2019-05-19, status=1, ipAttribution=)]
    2019-05-19 Zpril

    真的很实用

    0

  10. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue May 21 07:59:43 CST 2019, time=2019-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273782, encodeId=c35212e378290, content=<a href='/topic/show?id=fae896e7ea' target=_blank style='color:#2F92EE;'>#IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Mon May 20 17:10:00 CST 2019, time=2019-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503001, encodeId=bd6f150300192, content=<a href='/topic/show?id=129069358ec' target=_blank style='color:#2F92EE;'>#生物材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69358, encryptionId=129069358ec, topicName=生物材料)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89399597484, createdName=dongjia2013, createdTime=Mon May 20 17:10:00 CST 2019, time=2019-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551648, encodeId=5a2c1551648f0, content=<a href='/topic/show?id=e68d49e39c2' target=_blank style='color:#2F92EE;'>#异体移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49739, encryptionId=e68d49e39c2, topicName=异体移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bf7414204531, createdName=jianjun71, createdTime=Mon May 20 17:10:00 CST 2019, time=2019-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620733, encodeId=d8aa1620e3351, content=<a href='/topic/show?id=c0c9e520310' target=_blank style='color:#2F92EE;'>#移植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75203, encryptionId=c0c9e520310, topicName=移植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=153620156575, createdName=10518100zz, createdTime=Mon May 20 17:10:00 CST 2019, time=2019-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366446, encodeId=5d46366446e5, content=真的很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/05/19/1bcf1f4b388b5896583c0ccff1d4827e.jpg, createdBy=429b2531770, createdName=Zpril, createdTime=Sun May 19 14:06:34 CST 2019, time=2019-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366445, encodeId=4caa366445db, content=学习到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/05/19/1bcf1f4b388b5896583c0ccff1d4827e.jpg, createdBy=429b2531770, createdName=Zpril, createdTime=Sun May 19 14:00:01 CST 2019, time=2019-05-19, status=1, ipAttribution=)]
    2019-05-19 Zpril

    学习到了

    0

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