Brit J Cancer:争光霉素在治疗生殖细胞肿瘤使用中更佳临床指南研究

2018-11-07 AlexYang MedSci原创

争光霉素是一种具有细胞毒性的化学治疗药物,是淋巴瘤和生殖细胞瘤治疗方案中的关键组分。在极端案例中,甚至与重度中毒、长期并发症甚至死亡有关。在预防和控制争光霉素毒性方面缺乏相关证据或一致意见。最近,有研究人员调查了63名生殖细胞肿瘤医生,他们来自英国的32个癌症中心,从而来认识和理解他们使用争光霉素的方法。随后指南的开发基于目前的实践、最好的可利用的公开证据以及专家意见。研究人员在以下的领域中观察到

争光霉素是一种具有细胞毒性的化学治疗药物,是淋巴瘤生殖细胞瘤治疗方案中的关键组分。在极端案例中,甚至与重度中毒、长期并发症甚至死亡有关。在预防和控制争光霉素毒性方面缺乏相关证据或一致意见。

最近,有研究人员调查了63名生殖细胞肿瘤医生,他们来自英国的32个癌症中心,从而来认识和理解他们使用争光霉素的方法。随后指南的开发基于目前的实践、最好的可利用的公开证据以及专家意见。研究人员在以下的领域中观察到了实践的不均一性:监测、治疗方案、使用禁忌症、基线和跟踪调查的进行以及对患者的建议。研究人员开发了争光霉素在生殖细胞瘤治疗使用中的最好的临床实践,包括了基线调查的建议、肺功能测试的使用、治疗方案、监测和患者建议等方面。

最后,研究人员指出,现存的争光霉素开药临床实践的不均一性具有明显的经济、安全和患者经历影响。另外,他们的指南受到了93%的调查参与者的支持,并且能够解决相关问题和提供均一化的治疗。

原始出处:

Robert A. Watson, Hugo De La Pena, Maria T. Tsakok et al. Development of a best-practice clinical guideline for the use of bleomycin in the treatment of germ cell tumours in the UK. Brit J Cancer. 25 Oct 2018.

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    2018-11-07 lietome2

    认真学习,不断进步,把经验分享给同好。点赞了!

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