Respir Med Case Rep:过敏性肺炎患者的肺气肿变化

2018-07-11 MedSci MedSci原创

肺气肿最常见的原因是吸烟,但是在过敏性肺炎(HP)中也会出现肺气肿。本研究旨在进一步探究二者之间的关联。 1997年1月至2014年2月,研究人员在明尼苏达州罗切斯特的梅奥诊所进行了回顾性计算机辅助检索以确定HP患者。分析人口统计学临床和影像学特征。排除吸烟史为10包年或更长的患者。 最终研究确定了12名患有HP的患者(9名男性),计算机断层扫描确诊了肺气肿。10名患者为从不吸烟者,另外2名是戒烟

肺气肿最常见的原因是吸烟,但是在过敏性肺炎(HP)中也会出现肺气肿。本研究旨在进一步探究二者之间的关联。

1997年1月至2014年2月,研究人员在明尼苏达州罗切斯特的梅奥诊所进行了回顾性计算机辅助检索以确定HP患者。分析人口统计学临床和影像学特征。排除吸烟史为10包年或更长的患者。

最终研究确定了12名患有HP的患者(9名男性),计算机断层扫描确诊了肺气肿。10名患者为从不吸烟者,另外2名是戒烟者。诊断时的中位年龄为47(范围29-77)岁;中位症状持续时间为2.2(范围,0.2-13.4)年。最常见的症状是呼吸困难(83%)和咳嗽(67%)。肺功能检查中,6名患者(50%)具有限制性缺陷,2名(17%)存在气流阻塞,4名(33%)肺部一氧化碳弥散性能降低。肺气肿的严重程度从轻微到严重到局灶性肺大疱。所有患者均患有慢性过敏性肺炎(CHP)。5例间隔性肺气肿患者最常见并存中小叶中心性肺气肿。肺气肿最常见于上肺,也可见于其他肺叶。

综上所述,该研究结果表明,CHP患者可发生肺气肿,与吸烟史和接触特定类型的抗原无关。与网状/纤维化相比,气肿性变化的发展速度似乎较慢。

原始出处:


Baqir M, White D, et al., Emphysematous changes in hypersensitivity pneumonitis: A retrospective analysis of 12 patients. Respir Med Case Rep. 2018 Mar 22;24:25-29. doi: 10.1016/j.rmcr.2018.03.012. eCollection 2018.

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    2019-05-30 charl1234567
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    2018-07-12 yaanren
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    2018-07-11 131****1460

    学习了受益匪浅

    0