Nature重磅:少吃脂肪,能挽救你的头发

2021-09-26 “生物世界”公众号 “生物世界”公众号

近日,东京医科齿科大学的研究人员在国际顶尖学术期刊 Nature 上发表了题为:Obesity accelerates hair thinning by stem cell-centric conve

随着经济发展和生活水平的提高,在全世界范围内,肥胖已经成为了一个主要公共健康问题。据世界卫生组织(WHO)统计,全球有近20亿人超重或肥胖,从1975到2016年,全球肥胖率翻了近3倍,每年因超重或肥胖导致的死亡高达280万。

实际上,肥胖不仅导致生活不便、运动能力下降,肥胖还是一种疾病,肥胖者更易患代谢性疾病和心脑血管疾病,此外,许多研究表明,肥胖与十多种癌症的发病风险增加和预后及生存率降低有关。

然而,我们目前尚不完全清楚身体器官具体是如何因慢性肥胖而恶化和丧失功能的。

近日,东京医科齿科大学的研究人员在国际顶尖学术期刊 Nature 上发表了题为:Obesity accelerates hair thinning by stem cell-centric converging mechanisms 的研究论文。

该研究使用小鼠模型实验来研究高脂肪饮食或遗传因素的肥胖是如何导致脱发的。试验结果表明,高脂肪饮食或遗传因素的肥胖可通过诱导炎症信号导致毛囊干细胞(HFSC)枯竭,阻断毛囊再生,从而导致毛囊丢失,最终导致头发稀疏、脱发。

正常情况下,毛囊干细胞(HFSC)会在每个毛囊周期自我更新,这也是我们的头发能够不断长回来的过程中的一部分。

然而,随着年龄增长,毛囊干细胞逐渐无法自我补充,导致毛囊干细胞逐渐减少,从而导致头发稀疏。

虽然超重的人患雄激素性脱发的风险更高,但肥胖是否会加速头发脱落,其机制和分子机制在很大程度上是未知的。

实验结果表明,给予小鼠高脂肪饮食喂养,会消耗它们的毛囊干细胞,从而加速毛发稀疏,特别是在老年小鼠中。研究团队进一步比较了高脂肪饮食喂养的小鼠和标准饮食喂养的小鼠之间的毛囊干细胞的基因表达情况,并追踪了这些毛囊干细胞的命运。

结果发现,高脂肪饮食喂养导致肥胖的小鼠中的毛囊干细胞发生了命运改变,转变成了皮肤表面角质细胞或皮脂分泌细胞,这些小鼠表现出更快毛发脱落,更小的毛囊,以及毛囊干细胞的消耗。

该研究的通讯作者 Emi K. Nishimura 表示,即使仅仅连续四天的高脂肪饮食,毛囊干细胞也显示出氧化应激增加和表皮分化的迹象。高脂肪饮食喂养小鼠的毛囊干细胞中的基因表达表明毛囊干细胞内炎症细胞因子信号激活,这显着抑制了在毛囊再生中起关键作用的 Sonic Hedgehog 信号通路。

研究团队进一步表示,这也提示了我们,激活 Sonic Hedgehog 信号通路可以挽救毛囊干细胞的耗竭,防止高脂肪饮食带来的脱发问题。

总的来说,这项研究为高脂肪饮食或遗传性肥胖后可能发生的特定细胞命运变化和组织功能障碍提供了有趣的新见解,并可能为未来预防和治疗脱发以及了解肥胖相关疾病问题打开大门。

原始出处:

Morinaga, H., Mohri, Y., Grachtchouk, M. et al. Obesity accelerates hair thinning by stem cell-centric converging mechanisms. Nature 595, 266–271 (2021). https://doi.org/10.1038/s41586-021-03624-x.

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    2021-10-27 小林子omo

    学习了

    0

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    2021-10-15 ms6000000979092417

    学习了

    0

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    2021-12-12 liye789132251
  5. [GetPortalCommentsPageByObjectIdResponse(id=1079564, encodeId=404910e9564be, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/07fhMf2fBMs0JuLOO2VHbMGwXpzWL1VrM4jmXmzCJC1MJibjevdSx0x6y5pPnRuDjuziaR3av6ibgh5HtiaekpL9QA/132, createdBy=92592482325, createdName=埋藏在小清新下的重口味, createdTime=Mon Dec 13 14:52:13 CST 2021, time=2021-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1064523, encodeId=3db11064523f9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK8uiaErzMEKjF6nwnWWoodgybj9vEN4nZPZM0rIDn7oOzaL9jyRxYt8qH9huJ23qNia9oQoNGD7JqQ/132, createdBy=ca3e2470075, createdName=小林子omo, createdTime=Wed Oct 27 23:47:51 CST 2021, time=2021-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060872, encodeId=4bbf10608e2bc, content=学习了 , beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee145637254, createdName=ms6000000979092417, createdTime=Fri Oct 15 22:20:14 CST 2021, time=2021-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1885408, encodeId=81e2188540817, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sun Dec 12 23:00:03 CST 2021, time=2021-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468612, encodeId=015e146861272, content=<a href='/topic/show?id=7f7f443337a' target=_blank style='color:#2F92EE;'>#头发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44333, encryptionId=7f7f443337a, topicName=头发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f09e6924959, createdName=qindq, createdTime=Tue Sep 28 13:00:03 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1549727, encodeId=00161549e278a, content=<a href='/topic/show?id=f7879600061' target=_blank style='color:#2F92EE;'>#重磅#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96000, encryptionId=f7879600061, topicName=重磅)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3acc14121561, createdName=xxxx1054, createdTime=Tue Sep 28 13:00:03 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055322, encodeId=d4a51055322e0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210830/6e21298998ee404a98a9f9f18d4fd636/6dfb1526eb8d47dba5515dd0709385e8.jpg, createdBy=dc685586392, createdName=onebutton, createdTime=Mon Sep 27 13:09:27 CST 2021, time=2021-09-27, status=1, ipAttribution=)]
    2021-09-28 qindq
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    2021-09-28 xxxx1054
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    2021-09-27 onebutton

    学习了

    0

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