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Clin Chem：25-羟基维生素D与骨质疏松性骨折的风险

2020-07-17 MedSci原创 MedSci原创

骨折；风险
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目前，关于低血浆25-羟维生素D浓度是否会导致骨质疏松性骨折尚不清楚。本研究使用孟德尔随机分析对血浆25-羟基维生素D浓度低与骨质疏松性骨折风险增加相关的假设进行了验证。

目前，关于低血浆25-羟维生素D浓度是否会导致骨质疏松性骨折尚不清楚。本研究使用孟德尔随机分析对血浆25-羟基维生素D浓度低与骨质疏松性骨折风险增加相关的假设进行了验证。

研究人员随机选择了116 335名20-100岁的丹麦白人进行2项基于人群的队列研究，对CYP2R1 (rs117913124和rs12794714)、DHCR7 (rs7944926和rs11234027)、GEMIN2 (rs2277458)和HAL (rs3819817)基因型进行了研究，35833例患者包含血浆25-羟基维生素d的信息。研究人员评估了1981年至2017年期间发生全骨、骨质疏松和局部解剖性骨折的风险。从全国注册中心获取有关骨折和生命状态的信息。

在长达36年的随访中，研究人员观察到17820例骨折，10861例骨质疏松性骨折，3472例髋或股骨骨折。与25-羟基维生素D≥50nmol/L的个体相比，与25-羟基维生素D≥50nmol / L的个体相比，对于25–49.9 nmol / L的个体，总骨折的多变量调整后危险比（95％CI）为1.03（0.97–1.09），25-羟基维生素D <12.5 nmol / L的人为1.39（1.21-1.60），12.5-24.9nmol / L为1.19（1.10–1.28）。 骨质疏松性骨折和髋部或股骨骨折的相应危险比分别为1.07（1.00-1.15），1.25（1.13-1.37）和1.49（1.25-1.77），以及1.09（0.98-1.22），1.37（1.18-1.57）和1.41（1.09-1.81）。维生素D等位基因评分每增加1个风险比，即25-羟基维生素D浓度降低3.0%(约1.6 nmol/L)，全骨折的风险比为0.99(0.98 - 1.00)，骨质疏松性骨折的风险比为0.99(0.97-1.00)，髋或股骨骨折的风险比为0.98(0.95-1.00)。

研究结果表明，低血浆25-羟基维生素D浓度与骨质疏松性骨折相关；然而，孟德尔随机化分析并没有提供证据支持维生素D在骨质疏松性骨折风险中的因果作用。

原始出处：

Yunus Çolak,  Shoaib Afzal,25-Hydroxyvitamin D and Risk of Osteoporotic Fractures: Mendelian Randomization Analysis in 2 Large Population-Based Cohorts

 

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    2020-07-19 wangzheng00

    学习

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    2020-07-19 ms9651749636653578

    #骨质疏松性骨折#

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    2020-07-19 Eleven17

    #骨质#

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