诺华的Kymriah在血癌中表现出持久应答

2017-12-11 MedSci MedSci原创

在第59届美国血液学会(ASH)年会上提出的关于诺华CAR-T疗法Kymriah的试验数据的新分析显示,该药在6个月时对于难以治疗的血癌形式的成人持续完全应答。CAR-T提供了一种新的治疗方法,因为它是专门为每个病人制造的。在这个过程中,从患者的血液中提取T细胞,并在实验室中重新编程以创建基因编码的T细胞来狩猎患者的癌细胞。由宾夕法尼亚大学(Penn)的研究人员领导的"朱丽叶试验"(Juliet

在第59届美国血液学会(ASH)年会上提出的关于诺华CAR-T疗法Kymriah的试验数据的新分析显示,该药在6个月时对于难以治疗的血癌形式的成人持续完全应答。CAR-T提供了一种新的治疗方法,因为它是专门为每个病人制造的。在这个过程中,从患者的血液中提取T细胞,并在实验室中重新编程以创建基因编码的T细胞来狩猎患者的癌细胞。由宾夕法尼亚大学(Penn)的研究人员领导的"朱丽叶试验"(Juliet trial)的数据显示,在接受Kymriah(tisagenlecleucel)的患者中,患者的总体反应率(ORR)为53%,40%的患者获得完全反应(CR),患者部分应答率(PR)为14%。6个月时,30%的患者完全缓解,74%的患者在应答后无复发,然而没有达到中位缓解时间。这项研究的主要研究人员Stephen J. Schuster说:"在试验入选时,这些DLBCL患者已经经历了多轮化疗,许多患者干细胞移植失败,使得他们的选择不多,预后也很差。""使用tisagenlecleucel,我们已经能够显著提高他们实现和维持持续应答的机会,而无需干细胞移植,从而证明了这种治疗方法在治疗这种致命的

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    2018-07-26 grace5700
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    2017-12-13 liuhuangbo