JAHA:母乳喂养与孕产妇心血管风险降低有关

2022-01-12 MedSci原创 MedSci原创

世界卫生组织建议对出生后的儿童进行母乳喂养,母乳喂养与孕产妇心血管疾病结局风险降低相关。

世界卫生组织建议对出生后的儿童进行母乳喂养。具体而言,儿童应在出生后的头6个月内进行纯母乳喂养。母乳喂养与降低产妇乳腺癌卵巢癌和2型糖尿病的风险密切相关。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员在此系统地评估了已发表的关于母乳喂养与母亲心血管疾病(CVD)结局风险之间相关性的证据。

研究人员系统地检索了截至2021年4月16日发表的PubMed和Web of Science文章,确定了8项相关前瞻性研究,涉及1192700名经产妇女(加权平均年龄:研究开始时为51.3岁,第一次分娩时24.6岁;加权平均数出生人数为2.3人)。

该研究共有982566名女性(82%)报告曾进行过母乳喂养(母乳喂养的加权平均持续时间为15.6个月)。在10.3年的加权中位随访期间,共记录了54226例CVD、26913例冠心病、30843例卒中和10766例致命CVD事件。在一项随机效应荟萃分析中,将曾经母乳喂养的经产妇女与从未母乳喂养的经产妇女进行比较的汇总多变量调整风险比为0.89(95%CI为0.83-0.95;I2=79.4%),冠心病为0.86(95%CI为0.78-0.95;I2=79.7%),卒中为0.88(95%CI为0.79-0.99;I2=79.6%),致命性CVD为0.83(95%CI为0.76-0.92;I2=47.7%)。使用建议分级评估、开发和评估工具评估的证据质量从非常低到中等不等,这主要是由于研究之间的高度异质性所致。关联强度在进入研究时的平均年龄、中位随访时间、平均产次、调整水平、研究质量或地理区域方面没有差异。研究人员发现随着母乳喂养的持续时间从0个月到12个月,所有CVD结局的风险逐渐降低,但对于较长持续时间的关联形状存在一些不确定性。

由此可见,母乳喂养与孕产妇心血管疾病结局风险降低相关。

原始出处:

Lena Tschiderer.et al.Breastfeeding Is Associated With a Reduced Maternal Cardiovascular Risk: Systematic Review and Meta‐Analysis Involving Data From 8 Studies and 1 192 700 Parous Women.JAHA.2022.https://www.ahajournals.org/doi/10.1161/JAHA.121.022746

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    2022-01-14 zhaohui6731
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    2022-01-14 villahu

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