ASCO GI 2020:Zanidatamab在经过治疗的HER2+胃食管腺癌患者中显示出持久的抗肿瘤活性

2021-01-21 Allan MedSci原创

Zanidatamab是一种针对HER2的双特异性抗体。它同时结合了HER2细胞外域IV上的2个不同位点。这种独特的结合导致多种作用机制

ASCO GI 2020会议上发表的研究表明,Zanidatamab既可作为单一药物,也可与化学疗法联用,在经过治疗的人表皮生长因子受体2(HER2)阳性的胃食管腺癌患者中具有良好的耐受性和抗肿瘤活性。

德克萨斯大学安德森分校癌症中心的Funda Meric-Bernstam博士解释说:“Zanidatamab是一种针对HER2的双特异性抗体。它同时结合了HER2细胞外域IV上的2个不同位点。这种独特的结合导致多种作用机制”。

在I期研究的第1部分和第2部分中,患者接受了zanidatamab单药治疗(n = 36),在研究的第3部分中,患者接受了zanidatamab联合紫杉醇或卡培他滨的治疗(n = 26)。大多数患者先前接受过包括曲妥珠单抗在内的至少2种全身性治疗方案。

Meric-Bernstam博士说:“总的来说,仅使用单一疗法,客观缓解率为33%,疾病控制率为61%,反应持续时间为6个月。在接受zanidatamab联合紫杉醇或卡培他滨治疗的患者中,客观缓解率分别为50%和57%,疾病控制率分别为90%和71%。反应持续时间分别为9个月和5.8个月”。

 

原始出处:

https://www.firstwordpharma.com/node/1793073?tsid=4

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  5. 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  6. 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    2021-10-18 snf701207
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    2021-01-23 zhouqu_8
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