DDS: 动态甘油三酯水平对高甘油三酯血症性胰腺炎患者复发风险的影响

2019-04-21 不详 MedSci原创

甘油三酯严重影响胰腺炎患者的疾病发展,因此,本项研究旨在探究动态甘油三酯水平对高甘油三酯血症性胰腺炎患者复发性胰腺炎风险的影响。

背景及目的
甘油三酯严重影响胰腺炎患者的疾病发展,因此,本项研究旨在探究动态甘油三酯水平对高甘油三酯血症性胰腺炎患者复发性胰腺炎风险的影响。

方法
研究人员对2006年至2013年间在当地医院就诊的急性胰腺炎住院期间血清甘油三酯水平≥500mg / dL的患者进行了纵向回顾性队列研究(随访至2015年)。我们使用多变量稳健泊松回归来确定基线(首次门诊)甘油三酯测量对复发性胰腺炎风险的独立影响。门诊甘油三酯水平分为正常(0-200 mg / dL),中度升高(201-500 mg / dL)和高度升高(> 500 mg / dL)。我们进一步评估了与门诊患者血清甘油三酯(<200 mg / dL)正常化可能性相关的因素。

结果
151名患者符合研究纳入标准,中位随访时间为3年。总体而言,45名(29.8%)患者至少经历过1次复发,其中25名(16.6%)经历过多次发作。在多变量分析中,持续中度升高(RR 5.47(95%CI: 1.80,16.65))以及高度升高(RR 8.45(95%CI:2.55,27.96))甘油三酯的患者发生疾病复发的风险增加对于那些达到正常化的患者,在出院后30天内进行甘油三酯测量的患者更有可能达到正常化(40% VS 26%,p= 0.03)。

结论
对于高甘油三酯血症性胰腺炎患者,随后甘油三酯水平的适度升高与复发风险增加有关。

原始出处:

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