中国突破体细胞克隆猴世界难题 人类重大脑疾病诊治迎来光明前景

2018-01-25 李晋 国际在线 

中国科学院24日在北京宣布,经过中国科研工作者的不懈努力,2017年11月27日、12月5日,世界上首个体细胞克隆猴“中中”和妹妹“华华”先后诞生,中国因此成为第一个实现了非人灵长类动物体细胞克隆的国家。这一成果将为未来有效治疗脑疾病和中国人口健康领域的重大挑战做出贡献。



中国科学院24日在北京宣布,经过中国科研工作者的不懈努力,2017年11月27日、12月5日,世界上首个体细胞克隆猴“中中”和妹妹“华华”先后诞生,中国因此成为第一个实现了非人灵长类动物体细胞克隆的国家。这一成果将为未来有效治疗脑疾病和中国人口健康领域的重大挑战做出贡献。

自从1997年“多莉羊”体细胞克隆成功后,马、牛、骆驼、猫和狗等许多哺乳类动物的体细胞克隆也相继成功,但与人类相近的灵长类动物的体细胞克隆却一直是没有解决的世界性难题。位于上海的中国科学院神经科学研究所孙强研究员率领以博士后刘真为主的团队,经过五年的不懈努力,于近期成功地突破了这个生物学前沿的难题,世界上第一个体细胞克隆猴在中国诞生。中国科学院院长白春礼在24日的发布会上宣布:“2017年11月27日,世界上首个体细胞克隆猴“中中”诞生;12月5日第二个体细胞克隆猴“华华”诞生。该成果标志中国率先开启了以体细胞克隆猴作为实验动物模型的新时代。”

白春礼院长表示,体细胞克隆猴是依托中国科学院神经科学研究所、脑科学与智能技术卓越中心,完全由中国科学院团队独立完成的国际重大突破,实现了中国在非人灵长类研究领域由国际“并跑”到“领跑”的转变。该项目团队负责人中国科学院神经科学研究所孙强研究员表示:“我们一直在不断的优化摸索,没有放弃,头两年我们学习借鉴了国际上2010年之前的技术积累,然后继续不断试验,在最好的时机,大家也最努力,天时地利人和吧。”

体细胞克隆猴项目的成功在基础研究上有重大意义,同时,此项成果还将为解决中国人口健康领域的重大挑战做出贡献。白春礼院长解释说,目前绝大多数脑疾病之所以不能有效治疗,主要的原因之一是研发药物通用的小鼠模型和人类相差甚远,研发出的药物在人体检测时大都无效或有副作用。利用体细胞克隆技术制作脑疾病模型猴,为人类社会面临的重大脑疾病的机理研究、干预、诊治带来前所未有的光明前景:“体细胞克隆猴的成功,以及未来基于体细胞克隆猴的疾病模型的创建,将有效缩短药物研发周期,提高药物研发成功率,使我国率先发展出基于非人灵长类疾病动物模型的全新医药研发产业链,有力推动我国新药创制与研发,助力“健康中国2030”目标实现。”

未来,基于体细胞克隆猴的成功,中国将加快针对阿尔茨海默病、自闭症等脑疾病,以及免疫缺陷、肿瘤、代谢性疾病的新药研发进程。同时,以中国科学家为主导的灵长类全脑神经联接图谱国际大科学计划的实施和灵长类脑科学的前沿研究,将进一步使中国成为世界脑科学人才的汇聚高地。

中国科学院24日在北京宣布,经过中国科研工作者的不懈努力,2017年11月27日、12月5日,世界上首个体细胞克隆猴“中中”和妹妹“华华”先后诞生,中国因此成为第一个实现了非人灵长类动物体细胞克隆的国家。这一成果将为未来有效治疗脑疾病和中国人口健康领域的重大挑战做出贡献。


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    2018-10-11 aids221
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content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Jan 25 08:33:09 CST 2018, time=2018-01-25, status=1, ipAttribution=)]
    2018-01-26 天涯183

    非常好的文章.学习了

    0

  7. 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content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Jan 25 08:33:09 CST 2018, time=2018-01-25, status=1, ipAttribution=)]
    2018-01-26 曾超军

    厉害了

    0

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content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Jan 25 08:33:09 CST 2018, time=2018-01-25, status=1, ipAttribution=)]
    2018-01-25 120a4b15m88暂无昵称

    纯中医.当然要限制.开方应用西药!但科班出身的.都是中西结合教育的成果.不能一杆子打死!看他所从事的专业是什么来卷定!

    0

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content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Jan 25 08:33:09 CST 2018, time=2018-01-25, status=1, ipAttribution=)]
    2018-01-25 1e160a78m83(暂无匿称)

    厉害了

    0

  10. 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    2018-01-25 明月清辉

    谢谢分享.学习了

    0