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ASCO 2014：可切除的食管鳞癌患者围术期PCF化疗方案可改善生存

2014-05-31 刘揆亮 译 医学论坛网

ASCO2014生存食管癌
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可切除食管鳞状细胞癌患者中围术期化疗与术前化疗联合手术的比较 摘要号：#4037 第一作者：赵阳，西安交通大学附属第二医院 背景：我们在有可能治愈的食管鳞状细胞癌患者中评价了手术+围术期PCF(紫杉醇、 顺铂及氟尿嘧啶)方法与手术+术前化疗相比是否具有改善结局的作用。 方法：我们随机安排可切除的食管鳞状细胞癌患者接受围术期化疗(175名，A组)或术前化

可切除食管鳞状细胞癌患者中围术期化疗与术前化疗联合手术的比较

摘要号：#4037

第一作者：赵阳，西安交通大学附属第二医院

背景：我们在有可能治愈的食管鳞状细胞癌患者中评价了手术+围术期PCF(紫杉醇、 顺铂及氟尿嘧啶)方法与手术+术前化疗相比是否具有改善结局的作用。

方法：我们随机安排可切除的食管鳞状细胞癌患者接受围术期化疗(175名，A组)或术前化疗(171名，B组)加手术治疗。化疗方案为第1天静脉注射紫杉醇(200mg/m2体表面积)及顺铂(60mg/m2体表面积)，之后5天连续静脉输注氟尿嘧啶(700mg/m2体表面积)，术前重复2个周期(围术期组还有术后2个周期)。主要终点为无进展生存(PFS)，次要终点为总体生存(OS)。

结果：食管鳞状细胞癌患者中PCF相关不良反应与此前报告类似。围术期化疗+手术组与术前化疗+手术组术后并发症相似，术后30天内死亡率也相似。切除率和术后病理分期没有明显差异。所有患者50个月的中位随访时间内，围术期化疗组和术前化疗组分别有104名和114名患者死亡。与术前化疗+手术组相比，围术期化疗+手术组无进展生存可能性更大(进展危险比0.62， 95%可信区间0.49 -0.73;P< 0.001)，总体生存可能性也更大(死亡危险比0.79， 95%可信区间0.59-0.95;P< 0.001，5年生存率38 %与24%)。

结论：可手术的食管鳞状细胞癌患者中，围手术期PCF方案与术前化疗相比，可明显改善5年无进展生存和总体生存。临床试验信息：NCT01225523.

研究链接： Perioperative versus preoperative chemotherapy with surgery in patients with resectable squamous-cell carcinoma of esophagus: A phase III randomized trial. (Abstract 4037)

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    2015-03-24 木头人513

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    2015-01-31 quxin068

    #ASC#

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    2014-06-02 licz0423

    #围术期#

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    2014-06-02 zhouqu_8

    #食管#

    0

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    2014-06-02 1696533704_45270456

    #鳞癌#

    0

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题目：EGFR抑制剂耐药的非小细胞肺癌(NSCLC)患者中应用突变选择性EGFR抑制剂AZD9291的临床活性（Clinical activity of the mutant selective EGFR inhibitor AZD9291 in patients with EGFR inhibitor resistant non-small cell lung cancer (NS

ASCO 2014：局部进展期是食管鳞癌术前新辅助放化疗优于术后

新辅助治疗与辅助治疗相比哪种治疗对于可切除的局部进展期食管鳞状细胞癌更为有效？ 摘要号：#4060 第一作者：陈奇勋，浙江省肿瘤医院胸部肿瘤外科 背景：中国针对食管鳞状细胞癌（ESCC）的主要治疗为手术联合术后辅助放化疗。术前新辅助放化疗治疗的作用没有得到充分明确。我们在中国的一个ESCC人群中对新辅助放化疗后手术治疗及手术治疗后辅助放化疗的作用进行了比较。

ASCO 2014：MACC1基因对人胃癌淋巴管生成的影响

结肠癌转移相关基因-1对人胃癌淋巴管生成的影响 摘要号：#4042 第一作者：Sun Li，南方医科大学南方医院 背景：结肠癌转移相关基因-1（MACC1）是一种新型癌基因，主要表达于包括胃癌（GC）在内的几种实体瘤，与肿瘤淋巴结转移有关。GC的淋巴结转移对患者的临床转归有关键决定作用。因此，我们的研究评价了MACC1是否影响GC淋巴管转移，并探讨了其可能机制