Clinical Nutrition:习惯性摄入大豆蛋白和异黄酮能降低女性2型糖尿病的风险

2021-02-24 MedSci原创 MedSci原创

雌激素和雌激素受体通过调节胰岛素敏感性来影响组织中的胰岛素信号传导,在葡萄糖稳态中发挥作用,在氧化应激条件下间接保护胰腺B细胞功能。

      雌激素和雌激素受体通过调节胰岛素敏感性来影响组织中的胰岛素信号传导,在葡萄糖稳态中发挥作用,在氧化应激条件下间接保护胰腺B细胞功能。由于大豆异黄酮具有类似于雌激素(17 b-雌二醇)的化学结构,大豆蛋白和异黄酮的降糖作用引起了人们的关注。但是,饮食大豆获取异黄酮与降低2型糖尿病发生率之间存在联系的流行病学证据并不令人信服。因此,研究人员对年龄≥40岁的韩国成年人群体中饮食大豆蛋白和异黄酮的摄入与2型糖尿病风险之间的进行了前瞻性研究。

 

 

      共有8269名未患有2型糖尿病的参与者参加本项试验。使用食物频率调查表计算饮食中大豆蛋白和异黄酮摄入量。研究人员进行了超过50063人-年的随访,有531名参与者患有2型糖尿病。在女性中,饮食大豆蛋白与异黄酮(四分位数)和2型糖尿病之间存在显着的剂量反应关系(IRR = 0.63,95%CI = 0.45–0.87, P = 0.0078)。大豆蛋白和异黄酮都发现了相似的显着线性趋势。但是,男性中大豆蛋白和异黄酮没有显着关联。大豆蛋白和异黄酮的摄入量之间的关联在女性中非常明显,而在男性中则没有关联。

 

      习惯摄入大豆蛋白和异黄酮的女性可能与2型糖尿病发病成反比,而男性则不然。饮食中的大豆成分在男女2型糖尿病的发生中可能扮演不同的角色。

 

 

原始出处 :

Hye Won Woo. Et al. Sex-specific associations of habitual intake of soy protein and isoflavones with risk of type 2 diabetes. Clinical Nutrition.2021.

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    2021-03-07 fengyi821
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    2021-02-24 Jessica

    豆浆

    1

    展开1条回复
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    2021-02-26 zll0628
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    2021-02-24 王静6093

    学习了

    0

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    2021-02-24 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2021-02-24 jyzxjiangqin

    好文章!

    0