Cell Dis:南京大学李靓/张辰宇团队等在金银花防新冠研究中再取新成果

2020-09-18 生物世界 Bio生物世界

金银花煎剂中吸收的MIR2911充分且必要地抑制体外和人类受试者中的SARS-CoV-2复制,因此,希望人们可以放弃对传统医学的偏见,并进行临床追踪,以帮助控制新冠疫情大流行。

2020年8月5日,南京大学张辰宇教授团队、武汉病毒所张磊砢,及南京市第二医院易永祥等,在Cell Discovery 杂志发表论文,通过临床试验证实,金银花汤剂中的miRNA可通过饮用被人体有效吸收,并在体内有效抑制新冠病毒复制,加速新冠患者转阴,表明金银花汤剂治疗可能会极大地帮助治愈新冠患者并阻止COVID-19大流行。

2020年8月17日,南京大学张辰宇教授团队在 Cell Research 杂志发表了题为:SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs 的研究论文。

该研究发现,哺乳动物胃中的SIDT1蛋白介导食物miRNA的吸收,进而使其在动物体内发挥生物学功能。

2020年9月11日,南京大学李靓、张辰宇团队,及武汉病毒所张磊砢,南京市第二医院易永祥等在 Cell Discovery 杂志发表题为:Decreased HD-MIR2911 absorption in human subjects with the SIDT1 polymorphism fails to inhibit SARS-CoV-2 replication 的论文。

该研究报告了SIDT1多态性显着降低了人类对金银花汤剂中MIR2911的吸收。携带SIDT1多态性的志愿者中分离出的外泌体中具有较低水平的金银花MIR2911,并且不能抑制SARS-CoV-2的复制。

研究团队之前已经确定SID1跨膜家族成员1(SIDT1)是介导食物中miRNA吸收的关键膜蛋白,而SIDT1敲除小鼠无法吸收外源性miRNA。

在本研究中,他们证明了携带SIDT1多态性(Val78Met)的人群(16%)的频率很高。功能分析表明,与野生型SIDT1相比,体外实验证明这种多态性破坏了其在低pH条件下对外源miRNA的摄取。

此外,与SIDT1wt组相比,SIDT1poly志愿者血清外源性miRNA水平较低(?10%)。口服金银花汤后MIR2911的吸收在SIDT1poly群体中也显着下降。这些发现表明SIDT1在人类膳食miRNA摄取中的关键作用。

此外,SIDT1poly志愿者血清和血清外泌体中MIR2911水平较低。其对新冠病毒S蛋白表达以及对病毒复制没有效果。

值得注意的是,之前的临床研究中也发现,6名受试者中,唯一一名具有SIDT1多态性的新冠患者在接受金银花治疗后,其核酸转阴的时间明显长于其他患者(17天 vs 3.8天)。虽然需要更多的人类受试者来加强结论,但它清楚地表明MIR2911对于金银花汤的抗病毒作用是必不可少的。

总的来说,该研究的亮点在于:1、本研究提供了SIDT1介导人类膳食miRNA摄取的证据,进一步证实了其在外源miRNA吸收中的关键作用。2、结合以前的发现,清楚地表明MIR2911对于金银花汤对SARS-CoV-2的抗病毒作用是必要和充分的。

通讯作者李靓表示:“我们已经证明,金银花煎剂中吸收的MIR2911充分且必要地抑制体外和人类受试者中的SARS-CoV-2复制,因此,我们希望人们可以放弃对传统医学的偏见,并进行临床追踪,以帮助控制新冠疫情大流行。”

原始出处:
Zhen Zhou, Yu Zhou, Xia-Ming Jiang,et al. Decreased HD-MIR2911 absorption in human subjects with the SIDT1 polymorphism fails to inhibit SARS-CoV-2 replication.Cell Discov. 2020 Sep 11;6:63. doi: 10.1038/s41421-020-00206-5. eCollection 2020.

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createdName=wgx306, createdTime=Mon Sep 28 11:15:33 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2009492, encodeId=f713200949286, content=<a href='/topic/show?id=d9c136383c9' target=_blank style='color:#2F92EE;'>#南京大学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36383, encryptionId=d9c136383c9, topicName=南京大学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d590125, createdName=linlin2312, createdTime=Sat Dec 05 21:15:33 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025738, encodeId=64132025e389c, content=<a href='/topic/show?id=40005000427' target=_blank style='color:#2F92EE;'>#张辰宇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50004, encryptionId=40005000427, topicName=张辰宇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f32220, createdName=lancelotzzl, createdTime=Sat Aug 21 08:15:33 CST 2021, time=2021-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013478, encodeId=071f20134e8fe, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Dec 28 22:15:33 CST 2020, time=2020-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962283, encodeId=04571962283a3, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed Apr 21 02:15:33 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597002, encodeId=316c159e002f8, content=<a href='/topic/show?id=7bab96235f5' target=_blank style='color:#2F92EE;'>#金银花#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96235, encryptionId=7bab96235f5, topicName=金银花)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=40fa18449129, createdName=marongnuan, createdTime=Sun Sep 20 13:15:33 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886554, encodeId=edf58865541c, content=金银花,666, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df821667918, createdName=amyzhzh, createdTime=Sat Sep 19 02:52:22 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028571, encodeId=578e10285e172, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Sep 19 01:15:33 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886547, encodeId=b25f88654e55, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210821/a15e975aeb0e496195019b14e45cf422/c5f1efcb994044e8a80179b6a05fbd43.jpg, createdBy=c88d5419511, createdName=ms7000000042545438, createdTime=Sat Sep 19 00:06:27 CST 2020, time=2020-09-19, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1871982, encodeId=44cb18e198241, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon Oct 19 21:15:33 CST 2020, time=2020-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1922227, encodeId=bf90192222e79, content=<a href='/topic/show?id=33915836275' target=_blank style='color:#2F92EE;'>#新成果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58362, encryptionId=33915836275, topicName=新成果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4193478, createdName=wgx306, createdTime=Mon Sep 28 11:15:33 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2009492, encodeId=f713200949286, content=<a href='/topic/show?id=d9c136383c9' target=_blank style='color:#2F92EE;'>#南京大学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36383, encryptionId=d9c136383c9, topicName=南京大学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d590125, createdName=linlin2312, createdTime=Sat Dec 05 21:15:33 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025738, encodeId=64132025e389c, content=<a href='/topic/show?id=40005000427' target=_blank style='color:#2F92EE;'>#张辰宇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50004, encryptionId=40005000427, topicName=张辰宇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f32220, createdName=lancelotzzl, createdTime=Sat Aug 21 08:15:33 CST 2021, time=2021-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013478, encodeId=071f20134e8fe, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Dec 28 22:15:33 CST 2020, time=2020-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962283, encodeId=04571962283a3, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed Apr 21 02:15:33 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597002, encodeId=316c159e002f8, content=<a href='/topic/show?id=7bab96235f5' target=_blank style='color:#2F92EE;'>#金银花#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96235, encryptionId=7bab96235f5, topicName=金银花)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=40fa18449129, createdName=marongnuan, createdTime=Sun Sep 20 13:15:33 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886554, encodeId=edf58865541c, content=金银花,666, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df821667918, createdName=amyzhzh, createdTime=Sat Sep 19 02:52:22 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028571, encodeId=578e10285e172, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Sep 19 01:15:33 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886547, encodeId=b25f88654e55, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210821/a15e975aeb0e496195019b14e45cf422/c5f1efcb994044e8a80179b6a05fbd43.jpg, createdBy=c88d5419511, createdName=ms7000000042545438, createdTime=Sat Sep 19 00:06:27 CST 2020, time=2020-09-19, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1871982, encodeId=44cb18e198241, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon Oct 19 21:15:33 CST 2020, time=2020-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1922227, encodeId=bf90192222e79, content=<a href='/topic/show?id=33915836275' target=_blank style='color:#2F92EE;'>#新成果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58362, encryptionId=33915836275, topicName=新成果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4193478, createdName=wgx306, createdTime=Mon Sep 28 11:15:33 CST 2020, time=2020-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2009492, encodeId=f713200949286, content=<a href='/topic/show?id=d9c136383c9' target=_blank style='color:#2F92EE;'>#南京大学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36383, encryptionId=d9c136383c9, topicName=南京大学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d590125, createdName=linlin2312, createdTime=Sat Dec 05 21:15:33 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025738, encodeId=64132025e389c, content=<a href='/topic/show?id=40005000427' target=_blank style='color:#2F92EE;'>#张辰宇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50004, encryptionId=40005000427, topicName=张辰宇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f32220, createdName=lancelotzzl, createdTime=Sat Aug 21 08:15:33 CST 2021, time=2021-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013478, encodeId=071f20134e8fe, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Dec 28 22:15:33 CST 2020, time=2020-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962283, encodeId=04571962283a3, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed Apr 21 02:15:33 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597002, encodeId=316c159e002f8, content=<a href='/topic/show?id=7bab96235f5' target=_blank style='color:#2F92EE;'>#金银花#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96235, encryptionId=7bab96235f5, topicName=金银花)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=40fa18449129, createdName=marongnuan, createdTime=Sun Sep 20 13:15:33 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886554, encodeId=edf58865541c, content=金银花,666, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df821667918, createdName=amyzhzh, createdTime=Sat Sep 19 02:52:22 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028571, encodeId=578e10285e172, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Sep 19 01:15:33 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886547, encodeId=b25f88654e55, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210821/a15e975aeb0e496195019b14e45cf422/c5f1efcb994044e8a80179b6a05fbd43.jpg, createdBy=c88d5419511, createdName=ms7000000042545438, createdTime=Sat Sep 19 00:06:27 CST 2020, time=2020-09-19, status=1, ipAttribution=)]
    2021-04-21 爆笑小医
  7. [GetPortalCommentsPageByObjectIdResponse(id=1871982, encodeId=44cb18e198241, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon Oct 19 21:15:33 CST 2020, time=2020-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1922227, encodeId=bf90192222e79, content=<a href='/topic/show?id=33915836275' target=_blank style='color:#2F92EE;'>#新成果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58362, encryptionId=33915836275, topicName=新成果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4193478, 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  8. 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objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df821667918, createdName=amyzhzh, createdTime=Sat Sep 19 02:52:22 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028571, encodeId=578e10285e172, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Sep 19 01:15:33 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886547, encodeId=b25f88654e55, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2020-09-19 amyzhzh

    金银花,666

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df821667918, createdName=amyzhzh, createdTime=Sat Sep 19 02:52:22 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028571, encodeId=578e10285e172, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Sep 19 01:15:33 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886547, encodeId=b25f88654e55, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2020-09-19 公卫新人

    新冠肺炎,疫情何时才能消失

    0

  10. 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    2020-09-19 ms7000000042545438

    0

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