J Rheumatol:肉芽肿性多血管炎的冠脉疾病住院负担

2020-06-19 xiangting MedSci原创

研究发现与非GPA相比,这一全国性GPA住院患者样本中,CAD和伴HF的CAD负担在10年期间呈上升趋势,但AMI没有上升。

血管疾病是肉芽肿性多血管炎(GPA)的严重并发症。这项研究在一个GPA住院患者样本中,分析了冠状动脉疾病(CAD)的负担趋势及其两种严重表现,即急性心肌梗死(AMI)和心力衰竭(HF)。

研究人员使用国家住院患者样本进行了一项回顾性横断面分析。样本包括2005年至2014年住院治疗的GPA患者。分析了与无GPA患者相比,所有GPA住院患者CAD、AMI和HF比例的趋势。使用调整了潜在混杂因素的logistic回归,并包括相互作用。

在103,453例GPA住院患者中,20,351例(19.7%)住院患者同时被诊断为CAD。与伴CAD的非GPA患者相比,伴CAD的GPA患者传统心血管危险因素的总负担较低,慢性肾脏病除外(57%vs 21%)。10年研究期间,与非GPA对照相比,CAD(从2005年的16.6%上升到2014年的22.7%)和伴HF的CAD(从2005年的4.31%上升到2014年的9.88%)住院负担呈上升趋势,但AMI没有上升(从2005年的1.17%到2014年的1.11%)。

研究发现与非GPA相比,这一全国性GPA住院患者样本中,CAD和伴HF的CAD负担在10年期间呈上升趋势,但AMI没有上升。

原始出处:

Yiming Luo. Trends in the Inpatient Burden of Coronary Artery Disease in Granulomatosis with Polyangiitis: A Study of Large National Dataset. J Rheumatol. 15 June 2020.

 

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