JAHA:中年人成纤维细胞生长因子23与心血管疾病和死亡率的关系

2021-08-13 MedSci原创 MedSci原创

在合并症很少的中年人中,较高的cFGF23和iFGF23水平与较高的CVD事件或死亡风险并非独立相关。较高的cFGF23水平与较高的心力衰竭住院风险独立相关。

老年人循环中较高的成纤维细胞生长因子23(FGF23)水平与更高的心血管疾病(CVD)和死亡风险相关。FGF23水平与年轻人群心血管结局的关联尚未明确。  近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员测量了3151名中年人(平均年龄为45±4岁)FGF23C端(cFGF23)和完整的FGF23(iFGF23)水平,这些受试者参加了CARDIA(年轻人冠状动脉风险发展)研究的第20次检查。研究人员使用单独的Cox比例风险模型来评估cFGF23和iFGF23水平与CVD和死亡率之间的关联,并针对社会人口学、临床和实验室因素依次调整了模型。 受试者中位随访了7.6年(四分位距为4.1-9.9),共发生157起CVD事件和135例死亡病例。在完全调整的模型中,FGF23水平与CVD事件(cFGF23增倍对应的风险比:1.14,95%CI为0.97,1.34;iFGF23:0.76,95%CI为0.57,1.02)或全因死亡没有统计学上的显著关联(cFGF23增倍对应的风险比:1.17;95%CI为1.00,1.38;iFGF23为0.86;95%CI为0.64,

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    2021-08-15 zhaohui6731
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  8. 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  9. 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    2021-08-14 ms1000001521303206

    学习打卡

    0

  10. 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    2021-08-14 tanxingdoctor

    学习了,谢谢分享

    0

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应考虑对所有该研究中确定的高危患者优先接种疫苗。此外,需要对出现COVID-19的精神障碍患者进行密切监测和适当的医院转诊,以抵消可能减少的治疗机会。

Stroke:动脉瘤性蛛网膜下腔出血患者慢性肝病与死亡率之间的关系

在aSAH患者中,与非CLD相比,CLD与死亡率增加相关。在伴有CLD的aSAH患者中,较高的终末期肝病模型评分与死亡率增加相关。

Ann Rheum Dis:COVID-19 大流行对炎性关节病患者死亡率的影响

自2020年初COVID-19 大流行以来,很多风湿病患者不幸感染了新冠病毒。这项研究则评估了炎性关节病患者 (IJDs) 抗风湿治疗中COVID-19重症感染全因死亡的绝对和相对风险。

JAHA:经皮冠状动脉介入术后颅内出血的发生率、预测因素和对死亡率的影响

新发ICH最常发生在PCI后的早期,并且早期死亡的风险很高。对于ICH风险增加的患者,尤其是在PCI期间,需要谨慎使用抗血栓形成治疗。

Clin Res Cardiol:预测东亚HF患者死亡风险的新型风险评分

基于ML和新的连续变量分割算法的新型风险评分模型比传统预测模型在预测心衰患者死亡率方面的表现更好