Int J Cardiol:抑郁症、可治疗的心血管危险因素与心脏事件

2018-10-05 xing.T MedSci原创

由此可见,抑郁症与心脏事件之间的关联不太可能通过高血压、糖尿病或血脂异常的影响来解释。

抑郁症是血管疾病(CVD)的重要危险因素,而血管疾病是全球死亡的主要原因。这种关联的原因之一可能是抑郁症改变了可治疗的心血管危险因素与心脏事件(心绞痛或心肌梗塞)之间的关联。近日,心血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,研究人员在一项针对法国中年男性和女性的队列研究中检验了这一假设,并进行了20年随访。

研究人员对10541名基线(1993年)无心血管疾病的加泽尔工作男性和女性进行了20年以上针对已验证的心脏事件的随访,并通过流行病学研究中心-抑郁量表(CES-D)在基线和每三年测量一次抑郁症情况。研究人员使用时间依赖的Cox回归模型来计算与抑郁、主要可治疗的心血管危险因素(高血压糖尿病和血脂异常)相关的心脏事件风险比(HR)及其相互作用,调整了人口统计学指标、生活方式和临床特征。

在超过20年的随访期间,研究人员确定了592例心脏事件。抑郁症与心脏事件发生率显著相关(HR为1.55,P=0.002),高血压(HR为1.49,P=0.02)、糖尿病(HR为2.54,P=0.001)和血脂异常(HR为1.55,P=0.003)也是如此。抑郁症与心脏事件相关的高血压、糖尿病或血脂异常之间没有观察到统计学上显著的相互作用(所有P≥0.16)。

由此可见,抑郁症与心脏事件之间的关联不太可能通过高血压、糖尿病或血脂异常的影响来解释。

原始出处:

NadineM.Hamieh,et al.Depression, treatable cardiovascular risk factors and incident cardiac events in the Gazel cohort.International Journal of Cardiology.2018.https://doi.org/10.1016/j.ijcard.2018.10.013

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