JAHA:抑郁症状与心衰住院事件

2022-03-25 MedSci原创 MedSci原创

在基线时无CHD的个体中,抑郁症状与HFpEF事件住院有关,但与HFrEF或基线CHD无关。

心力衰竭(HF)是美国住院的主要原因。HF的患病率正在增加。美国国家健康和营养检查调查估计,2013年至2016年期间,美国成年人中有620万(2.2%)患有HF,而2009年至2012年期间为570万。HF患病率的增加归因于人口老龄化,重要的是,与射血分数降低的心力衰竭(HFrEF)相比,射血分数正常的心力衰竭(HFpEF)的患病率增加。

HFpEF和HFrEF是具有不同危险因素的两种不同的HF亚型。抑郁症状是包括冠心病(CHD)在内的多种心血管疾病的危险因素。然而,目前尚不清楚抑郁症状是否与HF相关,包括因HF整体或按亚型HFpEF和HFrEF的住院情况。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,在REGARDS(卒中地理和种族差异原因)研究的26268名无HF参与者中,这是一个美国社区居住的≥45岁成年人的前瞻性混血儿队列,基线抑郁症状被定义4项流行病学研究中心抑郁量表评分为4分以上。HF住院事件由专家所裁定,分为HFpEF(EF≥50%)和HFrEF,包括中等范围的EF(EF<50%)。

在中位9.2[IQR为6.2-10.9]年的随访中,有872例心衰住院,其中526例发生于无冠心病患者中,334例发生于有冠心病患者中。有抑郁症状的参与者每1000人每年的年龄调整HF住院发生率为4.9(95%CI为4.0-5.9),而没有抑郁症状的参与者为3.2(95%CI为3.0-3.5)(P<0.001)。对于整体HF,在控制协变量后升高的风险有所减弱。当单独评估HFpEF时,在控制无基线CHD的所有协变量(风险比[HR]为1.48,95%CI为1.00-2.18)后,抑郁症状与住院事件相关。相比之下,抑郁症状与HFrEF住院事件无关。

由此可见,在基线时无CHD的个体中,抑郁症状与HFpEF事件住院有关,但与HFrEF或基线CHD无关。

原始出处:

Yulia Khodneva,et al.Depressive Symptoms and Incident Hospitalization for Heart Failure: Findings From the REGARDS Study.JAHA.2022.https://www.ahajournals.org/doi/full/10.1161/JAHA.121.022818

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    2022-04-02 A lading

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    2022-03-26 zhaohui6731
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    2022-03-26 石头儿(石展)

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