AGING CELL:社会压力使寿命缩短

2018-05-30 海北 MedSci原创

这些数据突出了社会压力和低社会地位对缩短寿命和增加哺乳动物心血管疾病风险的保守作用,并确定了这种复杂现象的潜在机制。

人们承受的压力和较低的社会经济地位会增加患病率和死亡率。然而,这种关联在机理上并没有被理解,到目前为止,研究人员也没有在动物模型中探索它的因果关系。近来,细胞衰老被认为是将终身压力与年龄有关的疾病,以及人类预期寿命的缩短联系起来的潜在机制。

最近,来自明尼苏达大学的研究人员确立了终身社会压力在缩短寿命和增加小鼠心血管疾病风险方面的因果作用。具体来说,研究人员开发了一种终生的慢性社会心理压力模型,而后使用雄性小鼠的攻击性行为来研究消极的社会对抗对健康寿命和寿命的影响。

通过无偏聚集分析,研究人员发现接受高攻击性但表现出低攻击性的C57BL / 6J小鼠,或基于行为学标准鉴定为从属的小鼠,具有较低的中值寿命和最长寿命,并且在存在细胞衰老标记的情况下发生了几种器官病变的早期发作。重要的是,从属小鼠发生主动脉窦自发性早期动脉粥样硬化病变,其特征在于显着的免疫细胞浸润和散发性破裂和钙化,在非从属小鼠中均未发现。

总之,研究人员在这里介绍了一个啮齿动物模型,研究和在机理上解释慢性应激对寿命和衰老疾病的影响。这些数据突出了社会压力和低社会地位对缩短寿命和增加哺乳动物心血管疾病风险的保守作用,并确定了这种复杂现象的潜在机制。


原始出处:
Maria Razzoli et al. Social stress shortens lifespan in mice. Aging Cell, 2018. DOI: https://doi.org/10.1111/acel.12778s

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    2018-10-27 hb2008ye
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    2018-05-30 易水河

    自然而然的事情

    0

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    2018-05-30 186****0580(小山羊)

    学习了谢谢了

    0

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    2018-05-30 flysky120

    社会压力太大了慢慢自我缓解

    0

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    2018-05-30 龙胆草

    学习谢谢分享

    0

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    2018-05-30 王秀

    学习了.涨知识了!

    0

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    2018-05-30 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

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