Cell Death Dis:通过尿检朊病毒蛋白PrPC早期诊断肾损伤

2020-04-25 QQY MedSci原创

肾脏会遭受各种各样的伤害,并可将这些伤害转化为细胞水平的基本应激源。对这些应激的适应性反应主要通过在分子层面上消除或降低这些应激强度并促进代谢的重编程,进而维持细胞的稳态及其他重要的功能。

肾脏会遭受各种各样的伤害,并可将这些伤害转化为细胞水平的基本应激源。对这些应激的适应性反应主要通过在分子层面上消除或降低这些应激强度并促进代谢的重编程,进而维持细胞的稳态及其他重要的功能。

适应性应激反应影响了组织的内源性修复及瘢痕形成的平衡。因此,它们对于组织重塑至关重要,并可能影响受伤的肾脏功能,最终导致慢性肾脏疾病(CKD)。

内质网(ER)应激作为多种肾脏疾病发病机制的基础。识别和验证肾脏疾病早期阶段的内质网应激相关生物标志物对肾脏疾病患者的治疗至关重要。

该研究证明了在转录因子XBP1(x-box结合蛋白1)的调控下,朊病毒蛋白PrPC能够以常规方式由内质网应激的肾上皮细胞分泌,并可作为检测肾小管内质网应激反应的敏感性尿液生物标志物。慢性肾脏病患者的尿液的PrPC含量升高。

此外,在接受心脏手术的患者中,心脏分流术后可以检测到尿液中的PrPC含量也显著增加,这也与肾脏中的IRE1-XBP1通路激活有关。

总而言之,该研究发现,PrPC可以作为一种新型的内质网应激的生物标志物,在急性或慢性肾脏损伤的早期诊断中具有潜在作用。

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level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59464, encryptionId=1f4e5946422, topicName=早期诊断)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=71f1477, createdName=s_pl2008, createdTime=Mon Apr 27 08:58:29 CST 2020, time=2020-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397960, encodeId=e30c139e9604e, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Mon Apr 27 08:58:29 CST 2020, time=2020-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511531, encodeId=d6ce15115317c, content=<a href='/topic/show?id=a2724e42925' target=_blank style='color:#2F92EE;'>#尿检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47429, encryptionId=a2724e42925, topicName=尿检)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=207610348585, createdName=ms2999106592497887, createdTime=Mon Apr 27 08:58:29 CST 2020, time=2020-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531605, encodeId=32051531605bd, content=<a href='/topic/show?id=770e5e9457' target=_blank style='color:#2F92EE;'>#Death#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5794, encryptionId=770e5e9457, topicName=Death)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32e312278742, createdName=cy0328, createdTime=Mon Apr 27 08:58:29 CST 2020, time=2020-04-27, status=1, ipAttribution=)]
    2020-07-08 docwu2019
  5. 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createdAvatar=null, createdBy=32e312278742, createdName=cy0328, createdTime=Mon Apr 27 08:58:29 CST 2020, time=2020-04-27, status=1, ipAttribution=)]
  6. 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  7. 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  8. 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    2020-04-27 cy0328

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