Stroke:颈动脉支架成形术和颈动脉内膜切除术后的围手术期心肌梗死

2015-08-19 崔倩 译 MedSci原创

    与颈动脉内膜切除术(CEA)相比,颈动脉支架成形术(CAS)增加了围手术期卒中和死亡的风险。相反,在随机试验中CEA后心肌梗死(MI)的风险要高于CAS后。但是,发生数量很少,而且风险因素是未知的。    研究人员进行了系统回顾和荟萃分析,从1980年1月至2014年6月公布的研究和未发表的研究中收集数据。研究人员对预定义的9个危险因素(年龄,对侧颈

与颈动脉内膜切除术(CEA)相比,颈动脉支架成形术(CAS)增加了围手术期卒中和死亡的风险。相反,在随机试验中CEA后心肌梗死(MI)的风险要高于CAS后。但是,发生数量很少,而且风险因素是未知的。

研究人员进行了系统回顾和荟萃分析,从1980年1月至2014年6月公布的研究和未发表的研究中收集数据。研究人员对预定义的9个危险因素(年龄,对侧颈动脉闭塞,冠状动脉疾病,糖尿病,性别,高血压,外周动脉疾病,狭窄类型和临床表现)提取数据。研究人员选择的研究中至少有一个亚组的MI数据可用,并计算绝对和相对的风险,并确定了MI风险的不同影响。

CAS后心肌梗死的30天绝对危险为0.87%(95%置信区间,0.69-1.07),CEA后的绝对风险为0.70%(95%置信区间,0.54-0.88)(P=0.38)。CAS后,有症状的狭窄和再狭窄的患者心肌梗死的风险较高,而男性的风险较低。CEA后,年龄、冠状动脉疾病史、外周动脉疾病和再狭窄增加了心肌梗死的风险。CAS和CEA之间的差异只有性别造成的影响,即CAS后男性处于MI比女性风险较低,然而CEA后性别间无差异(P=0.01)。

CEA和CAS后MI的风险并没有显著差异。MI的危险因素在两种技术中整体相似,唯一的的不同之处在于CAS后男性的心梗风险较低,而CEA后没有这种情况。

原始出处:

Marion Boulanger, MD, Lucie Camelière, MD, Rui Felgueiras, MD, Ludovic Berger, PhD, Kittipan Rerkasem, PhD, Peter M. Rothwell, PhD and Emmanuel Touzé, PhD,Periprocedural Myocardial Infarction After Carotid Endarterectomy and Stenting,Stroke,2015.8.18

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