ERJ Open Res:短期吸入温盐水雾化气对非囊性纤维化支气管扩张患者的影响

2020-02-19 不详 网络

非囊性纤维化支气管扩张症倡导分泌清除,但在临床治疗中常常被忽略。本研究旨在探讨经超声加温雾化器吸入0.9%生理盐水对稳定的非囊性纤维化支气管扩张性脓性痰患者的影响。研究纳入了27名稳定患者,该试验包括每天3个月的UNW气雾剂治疗与每天3个月的口服祛痰药治疗。结果是生活质量(通过莱斯特咳嗽问卷(LCQ)评估),痰液特征,肺功能,6分钟步行距离(6MWD)和急性发作频率。结果显示,与基线相比,UNW可

非囊性纤维化支气管扩张症倡导分泌清除,但在临床治疗中常常被忽略。本研究旨在探讨经超声加温雾化器吸入0.9%生理盐水对稳定的非囊性纤维化支气管扩张性脓性痰患者的影响。

研究纳入了27名稳定患者,该试验包括每天3个月的UNW气雾剂治疗与每天3个月的口服祛痰药治疗。结果是生活质量(通过莱斯特咳嗽问卷(LCQ)评估),痰液特征,肺功能,6分钟步行距离(6MWD)和急性发作频率。

结果显示,与基线相比,UNW可使痰液粘度,痰液颜色,LCQ得分和6MWD显着改善(p <0.05),而UNW的痰液颜色,LCQ得分,6MWD和鼓气能力的改善明显优于经治疗的患者口服祛痰药(p <0.05)。肺功能,痰细胞学分类及痰中炎症因子治疗无明显差异。

综上所述,该研究结果表明,在非囊性纤维化支气管扩张症中使用UNW气雾剂疗法具有较小但显著的益处。但是,UNW不能改善炎症程度。

原始出处:

Zhong L, Xiong Y, et al., Effect of short-term inhalation of warm saline atomised gas on patients with non-cystic fibrosis bronchiectasis. ERJ Open Res. 2020 Feb 10;6(1). pii: 00130-2019. doi: 10.1183/23120541.00130-2019. eCollection 2020 Jan.

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    2020-07-22 wolongzxh
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    2020-10-29 feather89
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