PeerJ:精神分裂症患者口腔微生物分布与正常人存在差异

2015-08-27 MedSci 译 MedSci原创

乔治华盛顿大学的研究人员进行的一项研究表明,相比正常人而言,精神分裂症患者口咽部口腔细菌分布更广泛。该文章发表在PeerJ。 Eduardo Castro-Nallar评论道:“具体来说,我们的研究显示,精神分裂症与乳酸菌等微生物之间存在关联。”越来越多的研究表明,人体内病毒,细菌和真菌的存在会影响大脑的发育、行为和认知情况。此前,Medical News Today报道的研究显示,肠道菌群的变化

乔治华盛顿大学的研究人员进行的一项研究表明,相比正常人而言,精神分裂症患者口咽部口腔细菌分布更广泛。该文章发表在PeerJ。


Eduardo Castro-Nallar评论道:“具体来说,我们的研究显示,精神分裂症与乳酸菌等微生物之间存在关联。”

越来越多的研究表明,人体内病毒,细菌和真菌的存在会影响大脑的发育、行为和认知情况。

此前,Medical News Today报道的研究显示,肠道菌群的变化可以降低人大脑的认知功能,导致焦虑和抑郁,并使身体脂肪重新分布。

精神分裂症是一种复杂的精神障碍,其特征是认知功能、态度和情绪等反应的缺陷,影响机体心理健康。研究还表明,微生物会的存在会对机体免疫系统造成影响,这与精神分裂症的出现有一定关联。

在这项研究中,研究人员专注研究口咽部微生物,主要部位为位于口腔后部的区域,包括舌后三分之一、软腭、扁桃体和喉咙的侧壁和后壁。

既往研究发现,精神分裂症患者和普通人口腔细菌分布不同。在这项研究中,研究人员为16例精神分裂症患者何16位健康民众(对照组)检查了他们口腔的所有微生物。

研究人员报告,精神分裂症患者口腔微生物分布和对照受试者存在明显差异。对照组民众口腔微生物种类更多,但在其分布上却比精神分裂症患者更少;精神分裂症患者口腔中乳酸菌数目更多,包括乳酸杆菌和双歧杆菌。且既往研究已经表明,这两类细菌与机体免疫系统和情绪的调节存在关联;都柏林念珠菌这一真菌物种在精神分裂症患者口腔中也分布较多。研究人员认为,这种真菌的存在与机体免疫系统的改变和(或)当地环境的改变有关。

乔治华盛顿大学的计算生物学研究所所长Keith Crandall认为,这有可能作为检测精神分裂症患者的重要生物标记物,并有助于精神分裂症疾病的诊断。

但是该研究存在的一个混杂因素为吸烟因素,16名精神分裂症患者中有10名患者吸烟,对照组的参与者都不吸烟。既往研究表明,吸烟者和非吸烟者口腔的微生物种类和分布不同。

研究人员认为,如果能够有更大、更多样化的样本(如肠道微生物分布等)支持他们的研究结果,则这对揭示精神分裂症和微生物分布的潜在关系方面具有重要意义。

原始出处:

Eduardo Castro-Nallar et al.Composition, taxonomy and functional diversity of the oropharynx microbiome in individuals with schizophrenia and controls.PeerJ.25 August 2015.

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    2016-03-11 sjzlzc007
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    2016-04-29 feather89
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    2015-08-27 caierhong

    呵呵

    0

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    2015-08-27 lovetcm

    微生物研究有一点过头了,似乎什么疾病都和微生物有关,从肠道卫生,到口腔卫生。

    0

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