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J Mol Histol：Postn可促进骨质疏松患者的牙槽骨再生

2019-09-18 不详 网络

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骨质疏松症患者的骨再生受损。既往研究表明，periostin（Postn）在骨再生治疗中显示出巨大的潜力。然而，Postn在骨髓间充质干细胞（BMMSCs）中的作用仍有待阐明。在这项研究中，我们从卵巢切除大鼠（OVX-BMMSCs）和正常大鼠中分离出BMMSCs。然后，通过茜素红和碱性磷酸酶底物染色，qPCR和蛋白质印迹检测OVX-BMMSC中Postn和成骨的表达水平。我们发现OVX-BMMSC

骨质疏松症患者的骨再生受损。既往研究表明，periostin（Postn）在骨再生治疗中显示出巨大的潜力。然而，Postn在骨髓间充质干细胞（BMMSCs）中的作用仍有待阐明。

在这项研究中，我们从卵巢切除大鼠（OVX-BMMSCs）和正常大鼠中分离出BMMSCs。然后，通过茜素红和碱性磷酸酶底物染色，qPCR和蛋白质印迹检测OVX-BMMSC中Postn和成骨的表达水平。我们发现OVX-BMMSCs中的Postn水平明显降低。此外，使用重组慢病毒在OVX-BMMSCs中过表达可以改善碱性磷酸酶，瘤蛋白相关转录因子2和骨钙蛋白的表达，并降低硬化蛋白的表达。此外，微型计算机断层扫描分析，苏木精-伊红和Masson染色显示，使用Postn修饰的OVX-BMMSC片可以促进骨质疏松大鼠牙槽骨缺损的愈合。

总之，Postn修饰的OVX-BMMSCs可能恢复成骨能力，促进牙槽骨再生，这可能成为骨质疏松症骨再生的一种新的治疗方法。

原始出处：
 
Li D, Zhou W, Cao M. Periostin-modified bone marrow mesenchymal stem cells from osteoporotic rats promote alveolar bone regeneration. J Mol Histol. 2019 Sep 14. doi: 10.1007/s10735-019-09843-x.

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    2019-11-09 yuanming17

    #HIS#

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    2020-06-08 12498f1em08(暂无昵称)

    #牙槽骨再生#

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    2020-02-08 mei540

    #牙槽骨#

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    2019-09-20 lsj630

    #骨再生#

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    2019-09-20 智智灵药

    #骨质#

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