Cell Metab:或许,晚上运动效果更好...两篇研究探讨生物钟与运动表现

2019-04-21 佚名 中国生物技术网

近日,发表在《Cell Metabolism》上的两篇论文证实,生物钟是人体对运动做出反应的一个重要因素。这些研究侧重于运动的不同组成部分,从而相互补充。仅凭这些研究,还无法断言你一天之中适合运动的最佳时间,但至少实验室研究表明,晚间运动似乎更有成效。然而人,类的生活方式要复杂得多,因此这一领域的研究才刚刚开始。

近日,发表在《Cell Metabolism》上的两篇论文证实,生物钟是人体对运动做出反应的一个重要因素。这些研究侧重于运动的不同组成部分,从而相互补充。仅凭这些研究,还无法断言你一天之中适合运动的最佳时间,但至少实验室研究表明,晚间运动似乎更有成效。然而人,类的生活方式要复杂得多,因此这一领域的研究才刚刚开始。

该研究通讯作者、魏茨曼科学研究所生物分子科学系的Gad Asher说:“众所周知,我们生理和代谢的几乎每一个方面都是由生物钟决定的。这不仅只适用于人类,任何对光敏感的生物都是如此。因此,我们决定探究一天中的运动时间与运动效果之间是否存在联系。”

美国加州大学欧文分校表观遗传学和代谢中心的Paolo Sassone-Corsi说:“昼夜节律主导着我们所做的一切。我们实验室过去的研究表明,至少有50%的新陈代谢受到昼夜节律的影响,而且我们体内50%的代谢产物是随着昼夜周期而波动的。因此,运动也一定受到昼夜节律的影响。”

这两个研究团队都主要使用小鼠研究一天中的运动时间与运动效果之间的联系。因为小鼠是夜行动物,研究人员首先要做是将其节律转化为人类的节律。在研究中,他们是通过小鼠的“活跃阶段”和“休息阶段”进行区分,而非根据时钟上的时间数字。

Asher的研究团队让小鼠在每天活跃阶段的不同时间到跑步机上跑步,并测试了不同运动强度和运动方案下小鼠的运动能力。研究人员发现,小鼠们的运动表现在“小鼠的夜晚”中比在“小鼠的白天”中要好得多,平均高出50%,在某些记录中甚至更高。“小鼠的夜晚”指的是小鼠活跃阶段即将结束的时候。对于生物钟突变的小鼠来说,这种差异就存在了,这表明生物钟对运动表现具有潜在影响。

为了确定运动表现在一天之中变化的潜在决定因素,他们在小鼠肌肉组织上应用了高通量转录组和代谢组学方法。研究人员发现,在“小鼠的夜晚”中,运动产生的一种名为ZMP(5-氨基咪唑-4甲酰胺核苷酸)的代谢物水平更高。已知ZMP通过激活AMPK来激活与糖酵解和脂肪酸氧化有关的代谢途径,AMPK是细胞代谢的主要调节因子,因此,它可能有助于提高晚间的运动能力。Asher说:“有趣的是,ZMP是AICAR(氨基咪唑甲酰胺核苷)的一种内源性类似物,AICAR是一些运动员用于兴奋剂的化合物”

研究人员还对12名人类志愿者进行了研究,并取得了相似的发现。总的来说,志愿者们在晚间运动时的耗氧量比在白天更低,这表明他们在晚间的运动表现更好。

Sassone-Corsi的研究团队也对小鼠进行跑步机测试,但是采用了不同方法。他们利用高通量转录组和代谢组学方法对多种不同的因素进行了研究,并阐述了小鼠肌肉组织在运动后发生的变化。这使得他们能够观察到糖酵解和脂肪氧化(脂肪燃烧)等过程。

他们发现,一种名为低氧诱导因子1α(HIF-1α)的蛋白质起到重要作用,它通过不同的运动方式被激活,而这取决于一天中的时间。HIF-1α是已知基于组织中的氧水平刺激某些基因的转录因子。Sassone-Corsi说:“这很有意义,因为HIF-1α非常重要,但直到现在我们还不知道它根据一天中不同时间段的波动水平。这是一项新发现!”

基于加州大学欧文分校团队的研究结果,与在休息阶段(晚间)相比,在活跃阶段刚刚开始时(傍晚时分),运动对新陈代谢的影响最大。

研究人员注意到,尽管生物钟在整个演化过程中被保留下来,但将这些发现转化到人类并不是那么简单。一个原因在于,人类的睡眠类型比实验室小鼠要复杂得多。Sassone-Corsi说:“无论你是喜欢早起还是喜欢晚睡,这些事情都必须被考虑进去。”

原始出处:

[1]Saar Ezagouri,Ziv Zwighaft,Jonathan Sobel,et al.Physiological and Molecular Dissection of Daily Variance in Exercise Capacity,cell metab,April 18, 2019DOI:https://doi.org/10.1016/j.cmet.2019.03.012
[2]Shogo Sato,Astrid Linde Basse.Milena Sch?nke,et al.Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis,cell metab,April 18, 2019DOI:https://doi.org/10.1016/j.cmet.2019.03.013

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1896484, encodeId=53de1896484fa, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Oct 16 17:12:00 CST 2019, time=2019-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871233, encodeId=11d518e1233e7, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Oct 15 00:12:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961513, encodeId=46aa19615135a, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Feb 19 12:12:00 CST 2020, time=2020-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888009, encodeId=5503188800984, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed Dec 04 01:12:00 CST 2019, time=2019-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046802, encodeId=4d51104680266, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sun Apr 21 14:12:00 CST 2019, time=2019-04-21, status=1, ipAttribution=)]
    2019-10-16 一闲
  2. [GetPortalCommentsPageByObjectIdResponse(id=1896484, encodeId=53de1896484fa, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Oct 16 17:12:00 CST 2019, time=2019-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871233, encodeId=11d518e1233e7, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Oct 15 00:12:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961513, encodeId=46aa19615135a, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Feb 19 12:12:00 CST 2020, time=2020-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888009, encodeId=5503188800984, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed Dec 04 01:12:00 CST 2019, time=2019-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046802, encodeId=4d51104680266, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sun Apr 21 14:12:00 CST 2019, time=2019-04-21, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1896484, encodeId=53de1896484fa, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Oct 16 17:12:00 CST 2019, time=2019-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871233, encodeId=11d518e1233e7, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Oct 15 00:12:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961513, encodeId=46aa19615135a, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Feb 19 12:12:00 CST 2020, time=2020-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888009, encodeId=5503188800984, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed Dec 04 01:12:00 CST 2019, time=2019-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046802, encodeId=4d51104680266, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sun Apr 21 14:12:00 CST 2019, time=2019-04-21, status=1, ipAttribution=)]
    2020-02-19 维他命
  4. [GetPortalCommentsPageByObjectIdResponse(id=1896484, encodeId=53de1896484fa, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Oct 16 17:12:00 CST 2019, time=2019-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871233, encodeId=11d518e1233e7, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Oct 15 00:12:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961513, encodeId=46aa19615135a, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Feb 19 12:12:00 CST 2020, time=2020-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888009, encodeId=5503188800984, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed Dec 04 01:12:00 CST 2019, time=2019-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046802, encodeId=4d51104680266, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sun Apr 21 14:12:00 CST 2019, time=2019-04-21, status=1, ipAttribution=)]
    2019-12-04 guojianrong
  5. [GetPortalCommentsPageByObjectIdResponse(id=1896484, encodeId=53de1896484fa, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Oct 16 17:12:00 CST 2019, time=2019-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871233, encodeId=11d518e1233e7, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Oct 15 00:12:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961513, encodeId=46aa19615135a, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Feb 19 12:12:00 CST 2020, time=2020-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888009, encodeId=5503188800984, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed Dec 04 01:12:00 CST 2019, time=2019-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046802, encodeId=4d51104680266, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sun Apr 21 14:12:00 CST 2019, time=2019-04-21, status=1, ipAttribution=)]
    2019-04-21 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

相关资讯

Sports Medicine:晚上适度运动不影响睡眠,但睡前1小时不要剧烈运动

根据运动指南的建议,每周至少要做150分钟的适度运动。很多人鉴于白天没有时间,而不得不选择晚上锻炼,但又担心对睡眠产生负面影响