JCEM:孕妇甲状腺功能异常与子女不良结局的风险

2020-08-20 MedSci原创 MedSci原创

孕妇应考虑常规检测甲状腺功能,发生异常应及时治疗。

先前的研究表明孕妇甲状腺功能障碍与子女不良的神经认知结局和内脏器官发育受损之间可能存在关联。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在评估孕妇甲状腺功能障碍与子女不良结局风险之间的关联。

研究人员检索了PubMed、EMBASE和Cochrane数据库,选择了报告了孕妇甲状腺激素功能与其子女不良结局风险之间关联的研究。研究人员独立提取研究特征和结局数据,并汇总估计值,并报道了比值比(OR)和95%置信区间(CI),I2检测用于评估研究之间的异质性。

研究人员确定了29篇符合条件的文献,发现孕妇甲状腺功能亢进症与子女注意力缺陷多动障碍(ADHD)(OR:1.18,95%CI:1.04-1.34,I2=0%)和癫痫发作(OR:1.19,95%CI:1.08-1.31,I2=0%)之间存在关联;以及孕妇甲状腺功能减退症与子女ADHD(OR:1.14,95%CI:1.03-1.26,I2=25%)、自闭症谱系障碍(OR:1.41,95%CI:1.05-1.90,I2=63%)和癫痫发作(OR:1.21,95%CI:1.06-1.39,I2=0%)风险增加之间存在关联。

由此可见,孕妇应考虑常规检测甲状腺功能,发生异常应及时治疗。

原始出处:

Grace Mengqin Ge,et al.Maternal thyroid dysfunction during pregnancy and the risk of adverse outcomes in the offspring: a systematic review and meta-analysis.JCEM.2020.https://doi.org/10.1210/clinem/dgaa555

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    2020-08-20 Jessica

    有用!孕妇甲状腺功能不好,会给后代带来很多疾病风险。孕妇应考虑常规检测甲状腺功能,如果发生异常应及时治疗。#孕妇# #甲状腺功能障碍#

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    2021-01-29 achengzhao
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    2021-03-19 smallant2015
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