Clinica Chimica Acta:应用高灵敏度肌钙蛋白T测定法开发一种排除急诊科非ST段抬高心肌梗死的算法

2019-09-16 Gladiator MedSci原创

胸痛及其临床表现是急诊中最常见的病症。鉴于急诊科急性心肌梗死(AMI)引起胸痛的发生率较低,因此,临床医生应使用心肌肌钙蛋白安全快速排除AMI,避免低危患者延迟出院。

胸痛及其临床表现是急诊中最常见的病症。鉴于急诊科急性心肌梗死(AMI)引起胸痛的发生率较低,因此,临床医生应使用心肌肌钙蛋白安全快速排除AMI,避免低危患者延迟出院。

本研究旨在在有心肌梗死症状的ED患者中开发并验证一种算法,以便早期排除非st段抬高性心肌梗死(NSTEMI)。高灵敏度心肌肌钙蛋白Ths-cTnT)连续测量(基线,T0; 1小时后,T1; 3小时后,T3后)分别用于开发和验证该算法。

根据临床评估、诊断影像学和ofhs-cTnT系列测量结果,将患者分为NSTEMI患者和非NSTEMI患者;ROC曲线分析可以发现连续的ofhs-cTnT变化与诊断敏感性接近100%。只有hs-cTnTat T0低于14ng / L的患者才有资格安全排除NSTEMI

结果表明,虽然有些要点仍有待改进,但所得结果表明快速NSTEMI排除算法是可行和安全的。

原始出处:

Fabrizio CappelliniRosanna FalboDevelopment of an algorithm for ruling-out non-ST elevation myocardial infarction in the emergency department using high sensitivity troponin T assay

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    2020-04-27 respect
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    2019-11-25 windight
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encryptionId=6a426545472, topicName=测定)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8db925396819, createdName=丁鹏鹏, createdTime=Wed Sep 25 21:01:00 CST 2019, time=2019-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1926997, encodeId=e25a192699e3d, content=<a href='/topic/show?id=be549922826' target=_blank style='color:#2F92EE;'>#非ST段抬高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99228, encryptionId=be549922826, topicName=非ST段抬高)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5ed3112, createdName=echonoir, createdTime=Sat Sep 21 03:01:00 CST 2019, time=2019-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819112, encodeId=a7c818191123a, content=<a href='/topic/show?id=de2d99226e2' target=_blank style='color:#2F92EE;'>#非ST段#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99226, encryptionId=de2d99226e2, topicName=非ST段)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Thu Mar 26 12:01:00 CST 2020, time=2020-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282190, encodeId=ae2d128219096, content=<a href='/topic/show?id=4fd952582f1' target=_blank style='color:#2F92EE;'>#急诊科#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52582, encryptionId=4fd952582f1, topicName=急诊科)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570c172, createdName=tigerlr98, createdTime=Wed Sep 18 08:01:00 CST 2019, time=2019-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423093, encodeId=b78c1423093c2, content=<a 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time=2019-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569127, encodeId=a8c2156912e43, content=<a href='/topic/show?id=2651810889c' target=_blank style='color:#2F92EE;'>#肌钙蛋白T#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81088, encryptionId=2651810889c, topicName=肌钙蛋白T)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f7f15492758, createdName=huangdf, createdTime=Wed Sep 18 08:01:00 CST 2019, time=2019-09-18, status=1, ipAttribution=)]
    2019-09-25 丁鹏鹏
  5. [GetPortalCommentsPageByObjectIdResponse(id=2055580, encodeId=85cb2055580d5, content=<a href='/topic/show?id=25f09923421' target=_blank style='color:#2F92EE;'>#非ST段抬高心肌梗死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99234, encryptionId=25f09923421, topicName=非ST段抬高心肌梗死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19ad38, createdName=lq1767, createdTime=Wed Jun 17 17:01:00 CST 2020, time=2020-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775935, encodeId=42081e7593502, content=<a href='/topic/show?id=ede06694367' target=_blank style='color:#2F92EE;'>#灵敏度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66943, encryptionId=ede06694367, topicName=灵敏度)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  6. 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time=2019-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569127, encodeId=a8c2156912e43, content=<a href='/topic/show?id=2651810889c' target=_blank style='color:#2F92EE;'>#肌钙蛋白T#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81088, encryptionId=2651810889c, topicName=肌钙蛋白T)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f7f15492758, createdName=huangdf, createdTime=Wed Sep 18 08:01:00 CST 2019, time=2019-09-18, status=1, ipAttribution=)]
    2020-03-26 lxg951
  7. 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由此可见,ACS后早期停用阿司匹林会导致对花生四烯酸的血小板反应性增加,尽管联合有效的P2Y12受体阻滞剂治疗。

Lancet:老年非ST段抬高型心肌梗死或不稳定型心绞痛患者:介入治疗优于保守治疗

非ST段抬高心肌梗死(NSTEMI)和不稳定心绞痛是在老年人入院的常见原因。然而,针对这部分人群的临床试验是稀缺的,而这些病人不太可能按照指南接受治疗。该研究的目的是调查这个人群是否会受益于早期介入治疗 vs 保守策略。原始出处:Nicolai Tegn, Michael Abdelnoor,Lars Aaberge,et al.Invasive versus conservative strat