J Thorac Dis:感染性心内膜炎术前肾功能不全的危险因素和短期预后

2020-03-01 不详 网络

感染性心内膜炎(IE)并发肾功能不全的术后并发症发生率和院内死亡率较高。本研究旨在分析IE伴肾功能不全的临床特征,病因,诊断和治疗以及预后,并探讨肾损害的危险因素。回顾性分析了2008年至2017年在两个心脏中心接受瓣膜手术的IE患者。将其分为肾功能不全(RI)[内源性肌酐清除率(Ccr)<60 mL/min/1.73 m2]和正常肾功能(NRF)(Ccr≥60mL /min/1.73 m2

感染性心内膜炎(IE)并发肾功能不全的术后并发症发生率和院内死亡率较高。本研究旨在分析IE伴肾功能不全的临床特征,病因,诊断和治疗以及预后,并探讨肾损害的危险因素。

回顾性分析了2008年至2017年在两个心脏中心接受瓣膜手术的IE患者。将其分为肾功能不全(RI)[内源性肌酐清除率(Ccr)<60 mL/min/1.73 m2]和正常肾功能(NRF)(Ccr≥60mL /min/1.73 m2)组。比较两组的入院,病因,治疗和预后的疾病状况。对相关因素进行多元回归分析。

研究期间共进行了8055例瓣膜手术。我们分析了401名IE患者[平均年龄43.9±15岁;RI,n = 56(14%);NRF,n = 345(86%)],排除了2例原发性肾小球肾炎患者。RI患者的围手术期死亡率(14.3%VS.4.5%,P = 0.042)和链球菌感染(71.4%VS.43.8%,P = 0.001)更高。 RI组年龄较大,心脏功能较差,血红蛋白和血小板水平下降较大,人工瓣膜受累率较高,术后透析病例较多,预后较差(所有P <0.05)。二元逻辑多元回归分析表明,链球菌感染的发生率[比值比(OR)= 4.271,95%置信区间(CI),1.846-9.884;P = 0.001],年龄≥51岁(OR = 5.138、95%CI,2.258-11.694;P <0.001)和纽约心脏协会(NYHA)的III-IV级功能(OR = 10.768、95%CI,2.417-47.972;P = 0.002)是术前肾功能不全的独立危险因素。

总之,患有术前肾功能不全的IE患者死亡率高,预后差,链球菌感染易患肾功能不全的风险更高。此外,IE中年龄较大和心脏功能较差会导致肾功能不全的风险增加。

原始出处:

Yang Liu, Hang Zhang, et al., Risk factors and short-term prognosis of preoperative renal insufficiency in infective endocarditis. J Thorac Dis. 2018 Jun; 10(6): 3679–3688. doi: 10.21037/jtd.2018.06.11

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    2021-01-20 cmj8wellington
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    2020-12-17 yyj062
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    2020-04-24 yese
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