AJKD:终末期肾病女性患者心脑血管疾病的发病率和死亡率

2021-09-24 从医路漫漫 MedSci原创

心脑血管疾病是女性系统性红斑狼疮(SLE)发病率和死亡率的常见原因,也是终末期肾病(ESRD)患者的常见原因。

目的与方法:心脑血管疾病是女性系统性红斑狼疮(SLE)发病率和死亡率的常见原因,也是终末期肾病(ESRD)患者的常见原因。为了确定狼疮性肾炎引起的终末期肾病妇女是否比其他原因的终末期肾病妇女有更高的发病风险,研究人员利用美国肾脏数据系统的数据,比较了女性狼疮性肾炎引起的终末期肾病和其他原因引起终末期肾病导致急性心肌梗死和脑血管意外住院的发生率。

结果:在狼疮性肾炎引起的终末期肾病女性中,透析期间因急性心肌梗死住院的年龄和种族调整后的发生率为16.4/1000人年,对照组为17.3人/1000人年(调整后的危险比为0.80;95%可信区间[CI]为0.58至1.08;P5为0.14)。肾移植后急性心肌梗死的调整发病率在这些组之间也没有差异。在狼疮性肾炎引起的终末期肾病女性中,透析期间脑血管意外住院的调整发生率为18.5/1000人年,对照组为19.2次/1000人年(调整后危险比为0.87;95%CI为0.66至1.14;P5为0.30),肾移植后的发生率在不同组之间也没有差异。狼疮性肾炎引起的终末期肾病女性死于心脑血管疾病的风险也没有增加。脓毒症是这组人中最常见的死亡原因。糖尿病引起的终末期肾病妇女中急性心肌梗死和脑血管意外的发病率和死亡率要高得多。

表1 ESRD归因诊断急性心肌梗死住院发生率分析

表2 ESRD归因诊断脑血管意外住院发生率分析

表3 由ESRD的归因诊断得出的心血管疾病、脑血管事故、败血症和所有原因透析期间的死亡风险

表4 肾移植术后心血管疾病、脑血管意外、败血症和所有原因的死亡风险

结论:尽管心脑血管疾病的发病率和死亡率在SLE妇女中很常见,但在由狼疮性肾炎引起的ESRD妇女中,这些结果的风险并不比其他没有糖尿病的ESRD妇女更大。

原文出处:

Ward MM,Cardiovascular and cerebrovascular morbidity and mortality among women with end-stage renal disease attributable to lupus nephritis.Am J Kidney Dis 2000 Sep;36(3)

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    2021-09-25 查查佳佳

    思亲肤乐霜花店长推荐情侣装呢你是

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