AJG: 夜间胃食管反流事件与睡眠的关系

2020-05-04 MedSci原创 MedSci原创

夜间胃食管反流(nGER)症状通常与睡眠中断有关。大多数试图了解睡眠,唤醒和nGER事件之间关系的研究都是通过加速度计进行的。然而,该技术在精确确定睡眠和反流事件之间的时间关联方面的能力。

介绍及目的: 夜间胃食管反流(nGER)症状通常与睡眠中断有关。大多数试图了解睡眠,唤醒和nGER事件之间关系的研究都是通过加速度计进行的。然而,该技术在精确确定睡眠和反流事件之间的时间关联方面的能力有限。本项研究旨在使用高分辨率的实验室多导睡眠图(PSG)检查nGER事件与睡眠唤醒/唤醒之间的时间关系。

方法: 研究人员对18至70岁之间在12个月内接受胃镜检查的个体同时进行24小时pH /阻抗监测和实验室PSG。为每个参与者确定每个nGER事件与睡眠/唤醒/觉醒之间的时间关系。

结果: 研究人员对来自25个个体的数据进行了分析,其中64%患有nGER发作(每人5±5事件,范围1-18),其中64%患有阻塞性睡眠呼吸暂停(OSA,平均呼吸暂停-呼吸不足指数20±11,范围6–44事件/小时,)。有nGER的人和没有nGER的人在PSG决定的睡眠时间,睡眠效率,睡眠结构,唤醒/觉醒或睡眠呼吸暂停严重程度方面没有差异。大多数nGER事件(82%)发生在PSG时期。几乎在所有事件之前都进行了唤醒/唤醒(73/76),而在事件发生后进行了唤醒/唤醒的事件较少(15/76)。

讨论: 本项研究表明nGER似乎不会引起睡眠唤醒,而是因睡眠引起的对nGER的诱发。

Shepherd, Kelly. Et al. Temporal Relationship Between Night-Time Gastroesophageal Reflux Events and Arousals From Sleep. American journal of Gastroenterology. 2020.

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    2020-11-20 minzju5052
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    2020-05-06 zhouqu_8
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    2020-05-06 feifers

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