PNAS:研究减少常用药物副作用,有望药到病除

2018-02-28 佚名 Medicalxpress

澳大利亚国立大学(ANU)的最新研究已经深入到分子水平,以找到用于缓解疼痛,牙医麻醉和治疗癫痫的六种药物的相似之处,旨在寻找一种减少不必要的副作用的方法。

澳大利亚国立大学(ANU)的最新研究已经深入到分子水平,以找到用于缓解疼痛,牙医麻醉和治疗癫痫的六种药物的相似之处,旨在寻找一种减少不必要的副作用的方法。

五分之一的澳大利亚人患有慢性疼痛,25万澳大利亚人患有癫痫症,其中40%是儿童

到目前为止,研究人员已经知道,治疗疼痛和癫痫的药物是有效的,其中一些甚至自20世纪50年代以来一直用于临床。但是,由于采用了新技术,直到最近才开始研究它们如何工作以及为什么会产生副作用。

澳大利亚国立大学生物研究学院的Amanda Buyan博士表示,由于国家计算基础设施(NCI)在澳大利亚国立大学的超级计算能力,研究人员现在可以运行更大更复杂的模拟,以更好地了解发生了什么。

她说:“了解它们工作方式的分子细节,为我们提供了线索,说明为什么这些药物可能影响我们的身体,但也可能影响我们不希望影响身体的一部分。”

“理解这一点可以有希望为将来从事药物研发的科学家提供信息。”

布安博士希望这项研究能够更好地告诉科学家关于改变现有药物结构的可能性,或者设计一种新药以确保它能做到没有副作用。

“我希望这会导致药物被稍微改变,变得更加具体,或者产生更加有效的药物。”

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    2018-03-06 drwjr
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