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JAMA Oncology：高风险肾细胞癌肾切除术后Girentuximab辅助治疗

2017-07-11 MedSci MedSci原创

肾细胞癌肾切除术Girentuximab
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Girentuximab是一种结合了碳酸酐酶Ⅸ的嵌合式单克隆抗体，碳酸酐酶Ⅸ是肾透明细胞癌（ccRCC）细胞表明广泛表达的糖蛋白。在Ⅱ期研究中已验证了其安全性和活性，从而推进了其作为高风险ccRCC辅助治疗药物的进一步研究。JAMA Oncology近期发表了一篇文章，评估了Girentuximab辅助治疗对局部完全切除的高风险ccRCC患者无病生存（DFS）以及总生存（OS）的影响。

Girentuximab是一种结合了碳酸酐酶Ⅸ的嵌合式单克隆抗体，碳酸酐酶Ⅸ是肾透明细胞癌（ccRCC）细胞表明广泛表达的糖蛋白。在Ⅱ期研究中已验证了其安全性和活性，从而推进了其作为高风险ccRCC辅助治疗药物的进一步研究。JAMA Oncology近期发表了一篇文章，评估了Girentuximab辅助治疗对局部完全切除的高风险ccRCC患者无病生存（DFS）以及总生存（OS）的影响。

ARISER是一项随机双盲的Ⅲ期临床试验，研究时间为2004年6月到2013年4月2日。共有北美、南美以及欧洲15个国家142个中心参与。确诊为ccRCC的患者接受部分或根治性肾切除术。患者通过计算机随机分为试验组和安慰剂对照组。试验组在第1周接受50mgGirentuximab治疗后每周静脉注射Girentuximab 20mg（2-24周）。研究的主要终点是DFS和OS，次要终点包括安全性，不良事件发生率及程度。研究共纳入864例患者。与安慰剂组相比，接受Girentuximab治疗的患者DFS或OS并无显着改善。Girentuximab组平均DFS为71.4个月，安慰剂组未达到。185例患者出现药物相关不良反应（21.6%）。72例患者出现严重不良反应（8.4%）。接受安慰剂的患者出现1例药物相关严重不良反应。

文章最后认为，Girentuximab作为高风险ccRCC患者的辅助治疗方式无临床获益。患者表现出的长DFS和OS是ccRCC辅助治疗药物开发的挑战。

原始出处：
Karim Chamie,Nicholas M.Donin,et al.Adjuvant Weekly Girentuximab Following Nephrectomy for High-Risk Renal Cell Carcinoma.JAMA Oncology.July 2017 doi:10.1001/jamaoncol.2016.4419

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    2018-01-06 minlingfeng

    #Oncol#

    0

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    2017-07-31 snf701207

    #mAb#

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    2018-06-06 circumcision

    #Oncology#

    0

  4. 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content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Jul 13 06:41:56 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221438, encodeId=433422143891, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed Jul 12 15:12:02 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221305, encodeId=7fb5221305f1, content=希望能彻底治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Jul 12 07:20:13 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2018-04-02 doctorzheng

    #切除术#

    0

  5. 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content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Jul 13 06:41:56 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221438, encodeId=433422143891, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed Jul 12 15:12:02 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221305, encodeId=7fb5221305f1, content=希望能彻底治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Jul 12 07:20:13 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-11-02 zlawrance

    #高风险#

    0

  6. 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content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Jul 13 06:41:56 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221438, encodeId=433422143891, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed Jul 12 15:12:02 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221305, encodeId=7fb5221305f1, content=希望能彻底治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Jul 12 07:20:13 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-10-03 qingting

    #细胞癌#

    0

  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221305, encodeId=7fb5221305f1, content=希望能彻底治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Jul 12 07:20:13 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-08-25 gaoxiaoe

    #肾切除术#

    0

  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221305, encodeId=7fb5221305f1, content=希望能彻底治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Jul 12 07:20:13 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-07-13 龙胆草

    学习谢谢分享

    0

  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221305, encodeId=7fb5221305f1, content=希望能彻底治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Jul 12 07:20:13 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-07-12 清风拂面

    谢谢分享，学习了

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221305, encodeId=7fb5221305f1, content=希望能彻底治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Jul 12 07:20:13 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-07-12 flysky120

    希望能彻底治疗

    0

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肾癌是一种常见的并且具有侵入性的恶性肿瘤，并且该病的组织病理学并没有被人们完全理解。大多肾癌对细胞毒药物治疗具有抗性。最近，有研究人员利用两个肾癌小鼠模型来表述在人类乳头状肾细胞癌（pRCC）和透明细胞肾细胞癌（ccRCC）， 这两种是最为常见的肾细胞癌亚型。研究发现，MYC激活导致高度渗透的乳头状肾细胞癌肿瘤（MYC），然而，当MYC激活与Vhl 和 Cdkn2a(Ink4a/Arf) 缺失 (

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