Stroke:种族差异以及血管周围间隙对缺血性脑卒中的预后意义!

2017-05-13 MedSci MedSci原创

血管周围间隙(PVS)被认为是小血管疾病的标志物。然而,它们在短暂性脑缺血发作/缺血性卒中患者中的长期预后意义尚不清楚。目前,PVS流行率的种族差异也尚未可知。近期,一项发表在杂志Stroke上文章进行了两项独立的前瞻性研究,其中1例主要包括短暂性脑缺血发作/缺血性卒中的白人(OXVASC [Oxford Vascular]研究)),1例主要为缺血性卒中的中国人(香港大学)。随着年龄、性别、血管危

血管周围间隙(PVS)被认为是小血管疾病的标志物。然而,它们在短暂性脑缺血发作/缺血性卒中患者中的长期预后意义尚不清楚。目前,PVS流行率的种族差异也尚未可知。


近期,一项发表在杂志Stroke上文章进行了两项独立的前瞻性研究,其中1例主要包括短暂性脑缺血发作/缺血性卒中的白人(OXVASC [Oxford Vascular]研究)),1例主要为缺血性卒中的中国人(香港大学)。随着年龄、性别、血管危险因素和扫描仪强度的调整,研究了临床和影像学相关性,中风和死亡的预后意义以及基底神经节(BG)和中心半胱氨酸(CS)PVS的种族差异。

此项研究结果显示:与中国人相比,短暂性脑缺血发作/缺血性脑卒中的白人(n = 1028)患病率较高(n = 974;> 20 BG-PVS:22.4%vs 7.1%;> 20 CS-PVSs: 45.8%vs. 10.4%;P <0.0001)。尽管与BG-PVSs的关联性更强,但是,超过20BG或CS-PVS均与年龄增加和白质高信号相关(均P <0.0001)。

在6924例患者年随访期间,BG-PVSs也独立地与复发性缺血性卒中风险增加相关(调整后的风险比与<11 PVS相比,11-20 PVS:HR,1.15; 95%置信区间,0.78 -1.68;> 20 PVS:HR,1.82;1.18-2.80;P = 0.011),但与脑内出血(P = 0.10)或全因死亡率无关(P = 0.16)。CS-PVS与复发性卒中(P = 0.57)或死亡率无关(P = 0.072)。两组患者的预后关系相似。

此项研究结果表明:在短暂性脑缺血发作/缺血性脑卒中患者中,PVSs的频率差异超过种族差异,BG和CS-PVSs具有相似的危险因素;虽然> 20 BG-PVS与复发性缺血性卒中风险增加有关,但是CS-PVSs不相关。

原始出处:
Lau KK, Li L, et al. Clinical Correlates, Ethnic Differences, and Prognostic Implications of Perivascular Spaces in Transient Ischemic Attack and Ischemic Stroke. Stroke. 2017 May 11. pii: STROKEAHA.117.016694. doi: 10.1161/STROKEAHA.117.016694.

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    2017-05-28 cuiyejia

    学习了,谢谢

    0

  4. 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    2017-05-14 baihao215

    种族差异,似乎还在描述阶段

    0

  7. 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createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Sun May 14 08:57:34 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197615, encodeId=15b519e61571, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat May 13 15:56:56 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197609, encodeId=8bed19e609bf, content=学习了。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Sat May 13 15:43:58 CST 2017, time=2017-05-13, status=1, ipAttribution=)]
    2017-05-14 往日如昨

    学习了谢谢分享

    0

  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Sun May 14 11:36:52 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197944, encodeId=9f4919e944a2, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Sun May 14 11:12:10 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197906, encodeId=cee619e906c3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Sat May 13 15:43:58 CST 2017, time=2017-05-13, status=1, ipAttribution=)]
    2017-05-14 meiliwuxian

    学习了

    0

  9. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Sun May 14 11:36:52 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197944, encodeId=9f4919e944a2, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Sun May 14 11:12:10 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197906, encodeId=cee619e906c3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Sat May 13 15:43:58 CST 2017, time=2017-05-13, status=1, ipAttribution=)]
    2017-05-13 虈亣靌

    谢谢分享,学习了

    0

  10. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Sun May 14 11:36:52 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197944, encodeId=9f4919e944a2, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Sun May 14 11:12:10 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197906, encodeId=cee619e906c3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Sat May 13 15:43:58 CST 2017, time=2017-05-13, status=1, ipAttribution=)]
    2017-05-13 135****7952平儿

    学习了。。。。

    0