Complement Ther Med:S.officinalis提取物可预防多囊卵巢综合征患者的胰岛素抵抗

2020-10-01 MedSci原创 MedSci原创

本研究为一项随机、三盲、对照试验,旨在评估丹参(S.officinalis)提取物对多囊卵巢综合征(PCOS)患者 "人体测量指数 "和 "胰岛素抵抗标志物 "的影响。

本研究为一项随机、三盲、对照试验,旨在评估丹参(S.officinalis)提取物对多囊卵巢综合征(PCOS)患者 "人体测量指数 "和 "胰岛素抵抗标志物 "的影响,研究结果已在线发表于Complement Ther Med。

 

纳入根据鹿特丹标准诊断的60名PCOS患者。每天食用330mg口服S.officinalis提取物或安慰剂胶囊,持续8周。体重指数(BMI)、腰臀比(WHR)、血压、稳态模型评估-胰岛素抵抗(HOMA-IR)和定量胰岛素敏感性检查指数(QUICKI)。

 

结果显示,S. officinalis组的BMI显著下降(P = 0.001),但是,两组之间的WHR没有显著差异(P = 0.164)。虽然未能发现S.officinalis提取物对收缩压有显著影响(P = 0.283),但是多变量模型显示两组之间在舒张压方面存在显著差异(P = 0.025)。此外,与安慰剂相比,服用S. officinalis提取物可显著降低胰岛素(P <0.001)和HOMA-IR(P <0.001)的水平。与安慰剂组相比,S.officinalis提取物补充剂导致QUICKI(P < 0.001)的增加更大。

 

综上所述,该研究结果表明,S.officinalis提取物的剂量为330 mg/天,可降低血糖正常的PCOS患者的BMI和收缩压,并可增强胰岛素抵抗标志物。

 

原始出处:

 

Leila AminiFaraz Mojab, et al., Efficacy of Salvia officinalis extract on the prevention of insulin resistance in euglycemic patients with polycystic ovary syndrome: A double-blinded placebo-controlled clinical trial. Complement Ther Med. 2020 Jan;48:102245. doi: 10.1016/j.ctim.2019.102245. 

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    2021-07-01 zsyan
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    2021-05-06 xuyong536
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    2021-01-19 baoya
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    2021-02-09 kalseyzl
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