Circ Cardiovasc Imaging:左心房重构的影响因素有哪些?

2017-02-20 MedSci MedSci原创

由此可见,人群中左心房扩张在黑人和西班牙裔中比白人个体更常见,并与左心室的平行变化有关。左心房扩张可能是通过血压控制和内脏肥胖的发生所介导。

在一般人群中,虽然与左心室重塑的促进因素得到了很好的研究,然而,很少有研究数据描述与左心房(LA)结构变化有关的影响因素。最近,心血管领域权威杂志Circulation-Cardiovascular Imaging上针对这一问题发表了一篇研究文章。

研究人员采用心脏磁共振成像对来自于达拉斯心脏研究中的748名受试者的最大LA体积进行了2次测量,2次测量之间的平均间隔时间为8年。研究人员采用多变量线性回归评估了LA的体积变化(ΔLAV)与传统危险因素、生物学标志物、LV的几何形状、通过心脏磁共振成像评估的重构和整体与局部肥胖的详细测量(通过磁共振成像和双能X线骨密度仪)之间的相关性。

研究人员发现较大的ΔLAV与黑人和西班牙裔的种族/民族、收缩压的变化、左心室质量和Δ左心室质量、N末端脑钠肽前体和N末端脑钠肽前体的变化、体重指数独立相关(所有P<0.05)。在亚组分析中,对ΔLAV与左心室质量参数之间的相关性被基础舒张末期容积和Δ左心室舒张末期容积之间的相关性所驱动(每一个P<0.0001),而与心室壁厚度(P=0.21)无关。对ΔLAV与体重指数的相关性是由内脏脂肪质量相关性进行解释(P=0.002),而ΔLAV和腹部皮下脂肪之间(P=0.47)或低体脂(P=0.30)之间没有观察到相关性。

由此可见,人群中左心房扩张在黑人和西班牙裔中比白人个体更常见,并与左心室的平行变化有关。左心房扩张可能是通过血压控制和内脏肥胖的发生所介导。

原始出处:

Walter Oliver,et al. Factors Associated With Left Atrial Remodeling in the General Population. Circ Cardiovasc Imaging. 2017. https://doi.org/10.1161/CIRCIMAGING.116.00504

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    2017-05-19 ylz8411
  2. [GetPortalCommentsPageByObjectIdResponse(id=1659700, encodeId=e9ea1659e008e, content=<a href='/topic/show?id=da5c480e024' target=_blank style='color:#2F92EE;'>#左心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48070, encryptionId=da5c480e024, topicName=左心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50dc25016902, createdName=ylz8411, createdTime=Fri May 19 09:15:00 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938649, encodeId=f492193864916, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Tue Jun 13 22:15:00 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465530, encodeId=891f146553045, content=<a href='/topic/show?id=144f5032688' target=_blank style='color:#2F92EE;'>#影响因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50326, encryptionId=144f5032688, topicName=影响因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80a06745918, createdName=chenzhuanggui, createdTime=Wed Feb 22 13:15:00 CST 2017, time=2017-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626829, encodeId=0b991626829a2, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Wed Feb 22 13:15:00 CST 2017, time=2017-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=177338, encodeId=a30e1e7338bb, content=这个很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/30/dd6bade062cb598667f9f577194196c4.jpg, createdBy=422e1687020, createdName=Dr.jerry, createdTime=Wed Feb 22 01:19:17 CST 2017, time=2017-02-22, status=1, ipAttribution=)]
    2017-06-13 quxin068
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    2017-02-22 sodoo
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    2017-02-22 Dr.jerry

    这个很不错

    0

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