Stroke:结核性脑膜炎患者脑梗死的频率和影响

2018-09-15 xing.T MedSci原创

由此可见,脑梗塞使大部分TBM病例病情变得复杂。传统的血管危险因素是脑梗死的最重要的预测因素,未来的努力需要关注这些高风险的TBM患者,以降低发病率和死亡率。

脑梗塞使结核性脑膜炎(TBM)病例变得复杂,并对患者结局产生不利影响。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,该研究的目的是评估TBM患者脑梗塞的预测因素,并探究其对死亡率的影响。

该研究基于2002年至2013年间入住三级医院的所有TBM患者的回顾性病例审查。收集的数据包括基础人口统计学指标、常规血管危险因素、影像学检查结果、TBM严重程度和神经功能结局。研究人员进行二元logistic回归以确定预测脑梗塞和TBM患者死亡率的因素。

在研究期间共有559名TBM患者入选。平均年龄为41.9岁(标准差为17.7岁),47%为女性。四分之一的患者为III期疾病。114名(25.8%)患者在脑部影像学检查上证实存在脑梗塞,其中四分三的患者为急性或亚急性病例。脑梗塞患者更可能超过40岁(校正比值比[AOR]为1.7; 95%CI为1.1-2.7)以及为高血压(AOR为1.8; 95%CI为1.1-2.8)、血脂异常(AOR为9.7; 95%CI为3.8-24.8)和糖尿病(AOR为2.2; 95%CI为1.3-3.6)患者。脑梗死是TBM患者死亡率的独立预测因子(AOR为2.1; 95%CI为1.22-3.5)。

由此可见,脑梗塞使大部分TBM病例病情变得复杂。传统的血管危险因素是脑梗死的最重要的预测因素,未来的努力需要关注这些高风险的TBM患者,以降低发病率和死亡率。

原始出处:

Mohammad Wasay, et al. Frequency and Impact of Cerebral Infarctions in Patients With Tuberculous Meningitis.stroke.2018.https://www.ahajournals.org/doi/abs/10.1161/STROKEAHA.118.021301

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    2018-09-17 karmond

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