Arthritis Rheumatol:手部骨关节炎放射学和超声检测特征与局部压力疼痛阈值的关联

2020-01-07 xiangting MedSci原创

手部OA结构和炎症病变的严重程度高与指关节的压力疼痛阈值较低相关,这提示存在疼痛敏化。这项研究结果表明,手部OA的疼痛敏化可能是由结构和炎症病变引起的。

疼痛敏化导致了骨关节炎(OA)复杂的疼痛体验。手部OA影像学特征与临床评估的疼痛敏化之间的关系在很大程度上仍然未知。这项研究目的是在Nor‐Hand 研究中探讨手部OA结构和炎症特征与局部压力疼痛阈值之间的关系。

调整年龄、性别和BMI后,在多级回归分析中检查了结构性放射学严重性(Kellgren-Lawrence 0-4级和糜烂性关节病存在/不存在)和超声检测的炎症严重程度(滑膜炎灰度0-3级和多普勒活动性存在/不存在)与两个手指关节压力疼痛阈值的横断面关系。

共纳入285名患者的570个关节。结构和炎症的严重程度高与压力疼痛阈值较低有关(K-L分级每增加1级,调整β95CI-0.5-0.6-0.4),糜烂性vs非糜烂性关节,-1.4-1.8-0.9);滑膜炎灰度分级每增加1级,-0.7-0.9-0.6),有vs没有多普勒活动性的关节,-1.5-1.8-1.1))。

手部OA结构和炎症病变的严重程度高与指关节的压力疼痛阈值较低相关,这提示存在疼痛敏化。这项研究结果表明,手部OA的疼痛敏化可能是由结构和炎症病变引起的。

原始出处:

Pernille Steen Pettersen. Associations between radiographic and ultrasound‐detected features in hand osteoarthritis and local pressure pain thresholds. Arthritis Rheumatol. January 2020.

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    2020-12-05 lisa438
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    2020-01-09 lmm397
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    2020-01-09 zhaojie88
  6. [GetPortalCommentsPageByObjectIdResponse(id=1693112, encodeId=b599169311248, content=<a href='/topic/show?id=8b415458e69' target=_blank style='color:#2F92EE;'>#手部骨关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54587, encryptionId=8b415458e69, topicName=手部骨关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=913b29340103, createdName=shizhenshan, createdTime=Sat Jun 27 18:35:00 CST 2020, time=2020-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972689, encodeId=cb0919e268925, content=<a href='/topic/show?id=8a6a2e8839' target=_blank style='color:#2F92EE;'>#Arthritis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2788, encryptionId=8a6a2e8839, topicName=Arthritis)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Sun May 31 03:35:00 CST 2020, time=2020-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026657, encodeId=2dba202665e92, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Sat Dec 05 15:35:00 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266081, encodeId=933012660819e, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Jan 09 02:35:00 CST 2020, time=2020-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357355, encodeId=1ecb135e355c6, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jan 09 02:35:00 CST 2020, time=2020-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385637, encodeId=bfaf138563e0f, content=<a href='/topic/show?id=b3d05e3382b' target=_blank style='color:#2F92EE;'>#放射学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57338, encryptionId=b3d05e3382b, topicName=放射学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3bb506, createdName=kkunny, createdTime=Thu Jan 09 02:35:00 CST 2020, time=2020-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405954, encodeId=4e191405954d3, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Thu Jan 09 02:35:00 CST 2020, time=2020-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553619, encodeId=037b15536190c, content=<a href='/topic/show?id=839e9e33475' target=_blank style='color:#2F92EE;'>#阈值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97334, encryptionId=839e9e33475, topicName=阈值)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Jan 09 02:35:00 CST 2020, time=2020-01-09, status=1, ipAttribution=)]
    2020-01-09 kkunny
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    2020-01-09 仁医06
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    2020-01-09 docwu2019

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