JACC:青年血压和胆固醇水平升高,增加心血管事件

2019-07-17 国际循环编辑部 国际循环

血压(BP)和胆固醇是心血管疾病(CVD)的主要可改变风险因素,但青年期暴露对晚年CVD风险的影响尚未得到很好的量化。发表于JACC的一项研究,研究者探索评估青年期暴露于风险因素和晚期CVD风险的独立相关性,并考虑了后续的生活暴露。

血压(BP)和胆固醇是心血管疾病(CVD)的主要可改变风险因素,但青年期暴露对晚年CVD风险的影响尚未得到很好的量化。发表于JACC的一项研究,研究者探索评估青年期暴露于风险因素和晚期CVD风险的独立相关性,并考虑了后续的生活暴露。
 

(图引自原文献)

研究汇总来自6个美国队列的数据,观察从青年期到晚年的生命历程,并从18岁开始估算每个参与者的低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C),收缩压(SBP)和舒张压(DBP)的风险因素轨迹。计算青年(18~39岁)和成年后期(年龄≥40岁)的每个风险因素的时间加权平均暴露,并与后续冠心病(CHD),心力衰竭(HF)或卒中风险相关联。

结果显示,共纳入36 030名参与者。在中位随访17年期间,有4570例CHD,5119例HF和2862例卒中事件。当在模型中综合考虑青年和后期成人风险因素时,青年LDL-C≥100 mg/dl(与<100 mg/dl相比)与CHD风险增加64%相关,与后续成人暴露无关。同样,青年SBP≥130 mm Hg(与<120 mm Hg相比)与HF风险增加37%相关,青年DBP≥80 mm Hg(与<80 mm Hg相比)与21%风险增加相关。

研究提示,青年累积暴露于升高的SBP,DBP和LDL-C与晚年CVD风险增加相关,而与后期成人暴露无关。

 
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    2020-03-15 jyzxjiangqin

    青年血压的影响。

    0

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    2020-02-07 jyzxjiangqin

    青年血压和胆固醇水平的影响。

    0

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    2020-01-04 jyzxjiangqin

    青年血压和胆固醇水平的影响。

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=380524, encodeId=cd033805242a, content=青年血压的影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Mar 15 18:09:10 CST 2020, time=2020-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378999, encodeId=72853e899998, content=青年血压和胆固醇水平的影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Feb 07 18:50:35 CST 2020, time=2020-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377771, encodeId=82173e7771ec, content=青年血压和胆固醇水平的影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Jan 04 15:24:10 CST 2020, time=2020-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643624, encodeId=da94164362483, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Fri Nov 15 14:48:00 CST 2019, time=2019-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377249, encodeId=23053e724963, content=青年血压和胆固醇水平的影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Dec 21 17:51:48 CST 2019, time=2019-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1854442, encodeId=661a18544421f, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Mar 28 14:48:00 CST 2020, time=2020-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=373227, encodeId=f7dc3e322782, content=青年血压和胆固醇水平。, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu Sep 26 17:34:26 CST 2019, time=2019-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372665, encodeId=01b73e26650b, content=青年血压和胆固醇水平的关系。, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Sep 13 10:49:15 CST 2019, time=2019-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1326267, encodeId=ec8a132626e55, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Fri Jul 19 13:48:00 CST 2019, time=2019-07-19, status=1, ipAttribution=)]
    2019-12-21 jyzxjiangqin

    青年血压和胆固醇水平的影响

    0

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    2020-03-28 hbwxf
  7. [GetPortalCommentsPageByObjectIdResponse(id=380524, encodeId=cd033805242a, content=青年血压的影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Mar 15 18:09:10 CST 2020, time=2020-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378999, encodeId=72853e899998, content=青年血压和胆固醇水平的影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Feb 07 18:50:35 CST 2020, time=2020-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377771, encodeId=82173e7771ec, content=青年血压和胆固醇水平的影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Jan 04 15:24:10 CST 2020, time=2020-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643624, encodeId=da94164362483, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Fri Nov 15 14:48:00 CST 2019, time=2019-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=377249, encodeId=23053e724963, content=青年血压和胆固醇水平的影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Dec 21 17:51:48 CST 2019, time=2019-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1854442, encodeId=661a18544421f, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Mar 28 14:48:00 CST 2020, time=2020-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=373227, encodeId=f7dc3e322782, content=青年血压和胆固醇水平。, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu Sep 26 17:34:26 CST 2019, time=2019-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372665, encodeId=01b73e26650b, content=青年血压和胆固醇水平的关系。, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Sep 13 10:49:15 CST 2019, time=2019-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1326267, encodeId=ec8a132626e55, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Fri Jul 19 13:48:00 CST 2019, time=2019-07-19, status=1, ipAttribution=)]
    2019-09-26 jyzxjiangqin

    青年血压和胆固醇水平。

    0

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    2019-09-13 jyzxjiangqin

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