BMC Gastroenterology: 超声可以用来评估慢性病毒性肝炎患者的肝硬度和颈动脉弹性

2019-02-24 不详 MedSci原创

本研究旨在探究慢性病毒性肝炎患者肝脏硬度与颈动脉弹性之间的关系。研究人员使用声辐射力脉冲(ARFI)技术来测量肝脏的硬度,并使用射频(RF)血管定量超声技术来测量颈总动脉弹性和血管功能的变化。并以此比较二者的关系。

背景
本研究旨在探究慢性病毒性肝炎患者肝脏硬度与颈动脉弹性之间的关系。研究人员使用声辐射力脉冲(ARFI)技术来测量肝脏的硬度,并使用射频(RF)血管定量超声技术来测量颈总动脉弹性和血管功能的变化。并以此比较二者的关系。

方法
研究人员招募了乙型肝炎病毒(HBV)或丙型肝炎病毒(HCV)引起的慢性病毒性肝炎的患者217名。将患者分为两组,一组包含147名慢性乙型肝炎(CHB)患者(98名男性和49名女性,平均年龄46.5±12.2岁),另一组包括70名慢性丙型肝炎(CHC)患者(47名男性和23名)女性,平均年龄47.6±12.1岁)。此外,研究人员选择了64名健康年龄和性别匹配的参与者(43名男性和21名女性,平均年龄47.8±5.1岁)作为对照组。ARFI技术用于测量肝脏硬度,RF超声技术用于测量颈动脉弹性参数,包括内膜中层厚度(IMT),脉搏波速度(PWV),动脉壁扩张系数(DC),顺应性系数(CC) )硬化指数α和β,以及增强指数(Aix)。最后研究人员比较不同年龄组之间的颈动脉弹性参数与肝硬度之间的相关性。

结果
CHB和CHC组的ARFI值显着高于对照组(1.84±0.52 VS 1.04±0.11 m / s; 1.86±0.37 VS 1.04±0.11 m / s; P <0.001)。与对照组相比,CHB组和CHC组均显示相同顺序的IMT,但具有显着更高的弹性参数,如α和β,以及更低的DC和CC值(P <0.001)。CHC组的PWV显着高于对照组(7.98±1.42 vs. 6.09±0.90 m / s,P <0.001)。在CHB组中,所有参数包括ARFI,IMT,PWV,DC,CC,α和β,在两个年龄组之间有显着差异(P?<0.05)。在CHC组中,除ARFI外,所有参数包括IMT,PWV,DC,α和β在两个年龄组之间有显着差异(P <0.05)。相关分析和逐步多元线性回归分析表明,对于CHB患者,年龄是颈总动脉IMT的独立预测因子(R 2 = 0.468,F = 54.635,P <0.001)。对于CHC患者,年龄和血糖是颈总动脉IMT的独立预测因子(R 2 = 0.465,F = 29.118,P <0.001)。

结论
尽管基于ARFI和RF超声检测,CHB和CHC患者的颈动脉IMT并未显着高于对照组,但其功能弹性参数已经发生变化。该发现为病毒性肝炎患者血管疾病的临床诊断提供了有用的参考。

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    2019-12-27 howi
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  5. 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  6. 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createdBy=c49e75, createdName=qjddjq, createdTime=Tue Feb 26 05:50:00 CST 2019, time=2019-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504607, encodeId=8344150460e5b, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Feb 26 05:50:00 CST 2019, time=2019-02-26, status=1, ipAttribution=)]
    2019-10-12 许安
  8. 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target=_blank style='color:#2F92EE;'>#肝炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81241, encryptionId=dd7d8124144, topicName=肝炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Wed Jun 05 17:50:00 CST 2019, time=2019-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072469, encodeId=2e9c20e246983, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sat Oct 12 08:50:00 CST 2019, time=2019-10-12, status=1, ipAttribution=), 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  9. 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target=_blank style='color:#2F92EE;'>#肝炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81241, encryptionId=dd7d8124144, topicName=肝炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Wed Jun 05 17:50:00 CST 2019, time=2019-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072469, encodeId=2e9c20e246983, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sat Oct 12 08:50:00 CST 2019, time=2019-10-12, status=1, ipAttribution=), 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createdBy=c49e75, createdName=qjddjq, createdTime=Tue Feb 26 05:50:00 CST 2019, time=2019-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504607, encodeId=8344150460e5b, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Feb 26 05:50:00 CST 2019, time=2019-02-26, status=1, ipAttribution=)]
    2019-02-26 qjddjq
  10. 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综合方法展示出,通过使用RT-2D-SWE正确区分96%的患者的良、恶性FLL。

Gastroenterology: 无酒精下行胰腺囊肿消融是可行的

内镜超声(EUS)引导下乙醇灌洗胰腺囊肿,随后输注紫杉醇的疗法对于治疗粘液性胰腺囊肿是有效的。 然而,在3%-10%的患者中会出现相关的并发症,这可能与乙醇的导致炎症效应有关。 本项研究的目的是确定是否需要酒精进行有效的胰腺囊肿消融,如果从消融过程中消除酒精是否会提高并发症的发生率。